Basic information Safety Supplier Related

KT5720

Basic information Safety Supplier Related

KT5720 Basic information

Product Name:
KT5720
Synonyms:
  • (9R,10S,12S)-2,3,9,10,11,12-HEXAHYDRO-10-HYDROXY-9-METHYL-1-OXO-9,12-EPOXY-1H-DIINDOLO[1,2,3-FG:3',2',1'-KL]PYRROLO[3,4-I][1,6]BENZODIAZOCINE-10-CARBOXYLIC ACID, HEXYL ESTER
  • KT5720
  • PROTEIN KINASE INHIBITOR KT 5720
  • 9,12-Epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, hexyl ester, (9R,10S,12S)-
  • (9s,10s,12r)-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1h-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid hexyl ester
  • KT5720 - CAS 108068-98-0 - Calbiochem
  • InSolution KT5720 - CAS 108068-98-0 - Calbiochem
  • KT-5720 (KT5720)
CAS:
108068-98-0
MF:
C32H31N3O5
MW:
537.61
EINECS:
810-587-2
Product Categories:
  • antibiotic
  • Cyclic Nucleotide related
Mol File:
108068-98-0.mol
More
Less

KT5720 Chemical Properties

Boiling point:
715.0±60.0 °C(Predicted)
Density 
1.49±0.1 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
methanol: 5 mg/mL
form 
powder
pka
11.96±0.40(Predicted)
color 
white
More
Less

Safety Information

Hazard Codes 
Xi
Risk Statements 
36/38
Safety Statements 
26-36
WGK Germany 
-
10
HS Code 
29419090

MSDS

More
Less

KT5720 Usage And Synthesis

Chemical Properties

White solid

Definition

ChEBI: An organic heterooctacyclic compound that is 1H,1'H-2,2'-biindole in which the nitrogens have undergone formal oxidative coupling to positions 2 and 5 of hexyl (3S)-3-hydroxy-2-methyltetrahydrofuran-3- arboxylate (the 2R,3S,5S product), and in which the 3 and 3' positions of the biindole moiety have also undergone formal oxidative coupling to positions 3 and 4 of 1,5-dihydro-2H-pyrrol- -one.

Biological Activity

Potent, selective inhibitor of protein kinase A (K i = 60 nM). Has no effect on PKG or PKC (K i > 2 μ M). Reversibly arrests human skin fibroblasts in the G 1 phase. Also available as part of the Mixed Kinase Inhibitor Tocriset™ and PKA Tocriset™ .

KT5720Supplier

J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Email
jkinfo@jkchemical.com;market6@jkchemical.com
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801
Email
3bsc@sina.com
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Sigma-Aldrich
Tel
021-61415566- ;
Email
orderCN@merckgroup.com;orderCN@merckgroup.com