8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT
8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT Basic information
- Product Name:
- 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT
- Synonyms:
-
- 8-BROMOADENOSINE-3',5'-CYCLIC * MONOPHOSPHOROTHIOAT
- 8-Bromoadenosine-3'',5''-cyclic monophosphothioate Rp isomer
- RP-8-BR-CAMPS
- RP-8-BR-CAMPS, NA
- RP-8-BR-CAMPS SODIUM SALT
- 8-bromoadenosine-3’,5’-cyclicmonophosphorothioate,rp-isomer(rp-8-br-camps),sodiumsalt
- 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT
- 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT, RPISOMER
- CAS:
- 129735-00-8
- MF:
- C10H11BrN5O5PS
- MW:
- 424.17
- Mol File:
- 129735-00-8.mol
8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT Chemical Properties
- Boiling point:
- 690.3±65.0 °C(Predicted)
- Density
- 2.70±0.1 g/cm3(Predicted)
- storage temp.
- −20°C
- form
- solid
- pka
- -0.60±0.60(Predicted)
- Water Solubility
- water: 40mg/mL
Safety Information
- Safety Statements
- 22-24/25
- WGK Germany
- 3
8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT Usage And Synthesis
Uses
Rp-8-Br-cAMPS is an analog of cAMP and an inhibitor of PKA. Rp-8-Br-cAMPS occupies cAMP binding sites on PKA type I regulatory subunits, thereby preventing PKA dissociation and activation. Rp-8-Br-cAMPS can be used in the study of tumors and retrovirus-induced immune deficiency. Rp-8-Br-cAMPS also inhibits insulin secretion[1][2][3].
Biological Activity
Cell permeable: yes', 'Primary Target
PKA 1', 'Product does not compete with ATP.', 'Reversible: yes
in vivo
Rp-8-Br-cAMPS (1 mg; intraperitoneal injection; 10 days) improves immune function in a mouse retrovirus infection model[3].
| Animal Model: | Murine leukemia retrovirus RadLV-Rs treated male C57BL/6 mice[3] |
| Dosage: | 1 mg |
| Administration: | Intraperitoneal injection (i.p.); 10 days |
| Result: | Had no significant effect on the extent of lymphadenopathy and splenomegaly which is typical of RadLV-Rs retroviral infection. Strongly increased responses to the anti-CD3 mAb. Improved T cell responses. |
References
[1] Raskovalova T, et al. Adenosine-mediated inhibition of cytotoxic activity and cytokine production by IL-2/NKp46-activated NK cells: involvement of protein kinase A isozyme I (PKA I). Immunol Res. 2006;36(1-3):91-9. DOI:10.1385/IR:36:1:91
[2] Yang S, et al. Enhanced cAMP protein kinase A signaling determines improved insulin secretion in a clonal insulin-producing beta-cell line (INS-1 832/13). Mol Endocrinol. 2004 Sep;18(9):2312-20. DOI:10.1210/me.2004-0148
[3] Nayjib B, et al. In vivo administration of a PKA type I inhibitor (Rp-8-Br-cAMPS) restores T-cell responses in retrovirus-infected mice[J]. The Open Immunology Journal, 2008, 1(1).
8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALTSupplier
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8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT(129735-00-8)Related Product Information
- A-3 HYDROCHLORIDE
- 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT
- MALANTIDE
- N-(2-(METHYLAMINO)ETHYL)ISOQUINOLINE-
- HA-1004 DIHYDROCHLORIDE
- ARG-ARG-LYS-ALA-SER-GLY-PRO
- 8-(4-CHLOROPHENYLTHIO)-ADENOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT
- Adenosine 3',5'-cyclic monophosphate sodium salt
- 8-CHLORO-CAMP
- PROTEIN KINASE A INHIBITOR 14-22 AMIDE, CELL-PERMEABLE, MYRISTOYLATED
- SP-ADENOSINE 3',5'-CYCLIC MONOPHOSPHOTHIOATE TRIETHYLAMINE
- 8-BROMO-2'-DEOXYADENOSINE
- SODIUM O,O-DIETHYLTHIOPHOSPHATE
- 8-BROMOADENOSINE
- ADENOSINE-3',5'-CYCLIC -MONOPHOSPHOROTHIOATE
- 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT
- sodium O,O-dimethyl thiophosphate
- 8-BROMO-2'-O-MONOBUTYRYLADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT