MALANTIDE Chemical Properties

Density 

1.46±0.1 g/cm3(Predicted)

storage temp. 

−20°C

solubility 

H₂O: 1 mg/mL

pka

3.38±0.10(Predicted)

form 

powder

color 

white

Sequence

Arg-Thr-Lys-Arg-Ser-Gly-Ser-Val-Tyr-Glu-Pro-Leu-Lys-Ile

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

MALANTIDE Usage And Synthesis

Uses

Malantide is a synthetic dodecapeptide derived from the site phosphorylated by cAMP-dependent protein kinase (PKA) on the β-subunit of phosphorylase kinase. Malantide is a highly specific substrate for PKA with a Km of 15 μM and shows protein inhibitor (PKI) inhibition >90% substrate phosphorylation in various rat tissue extracts[1]. Malantide is also an efficient substrate for PKC with a Km of 16 μM[2].

References

[1] Murray KJ, et al. Use of a synthetic dodecapeptide (malantide) to measure the cyclic AMP-dependent protein kinase activity ratio in a variety of tissues. Biochem J. 1990 May 1;267(3):703-8. DOI:10.1042/bj2670703
[2] Z H Zhao, et al. Characterization of a New Substrate for Protein Kinase C: Assay by Continuous Fluorometric Monitoring and High Performance Liquid Chromatography. Biochem Biophys Res Commun. 1991 May 15;176(3):1454-61. DOI:10.1016/0006-291x(91)90450-l

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