TCO-PEG3-acid
TCO-PEG3-acid Basic information
- Product Name:
- TCO-PEG3-acid
- Synonyms:
-
- TCO-PEG3-acid
- TCO4-PEG3-COOH
- 5,8,11-Trioxa-2-azatetradecanedioic acid, 1-(4-cycloocten-1-yl) ester
- 1-(Cyclooct-4-en-1-yloxy)-1-oxo-5,8,11-trioxa-2-azatetradecan-14-oic acid
- CAS:
- 2141981-86-2
- MF:
- C18H31NO7
- MW:
- 373.44
- Product Categories:
-
- SiChem
- Mol File:
- 2141981-86-2.mol
TCO-PEG3-acid Chemical Properties
- Boiling point:
- 544.9±50.0 °C(Predicted)
- Density
- 1.15±0.1 g/cm3(Predicted)
- solubility
- Soluble in DMSO, DCM, DMF
- pka
- 4.28±0.10(Predicted)
- form
- Oil
- color
- Colorless to light yellow
TCO-PEG3-acid Usage And Synthesis
Description
TCO-PEG3-acid is a click chemistry PEG linker with a terminal carboxylic acid(CO2H) group. The terminal carboxylic acid is reactive with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. This reagent can react with tetrazine-containing compounds to form a stable covalent bond. The inverse-electron demand Diels-Alder cycloaddition reaction of TCO with tetrazines is the fastest bioorthogonal reaction with exceptional selectivity.
Uses
TCO-PEG3-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. TCO-PEG3-acid is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
IC 50
PEGs
References
[1] Wang Y, et al. Degradation of proteins by PROTACs and other strategies. Acta Pharm Sin B. 2020 Feb;10(2):207-238. DOI:10.1016/j.apsb.2019.08.001
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