TCO4-PEG3-NHS
TCO4-PEG3-NHS Basic information
- Product Name:
- TCO4-PEG3-NHS
- Synonyms:
-
- TCO4-PEG3-NHS
- 5,8,11-Trioxa-2-azatetradecanedioic acid, 1-(4-cycloocten-1-yl) 14-(2,5-dioxo-1-pyrrolidinyl) ester
- 2,5-dioxopyrrolidin-1-yl (Z)-1-(cyclooct-4-en-1-yloxy)-1-oxo-5,8,11-trioxa-2-azatetradecan-14-oate
- 2,5-Dioxopyrrolidin-1-yl (E)-1-(cyclooct-4-en-1-yloxy)-1-oxo-5,8,11-trioxa-2-azatetradecan-14-oate
- CAS:
- 2141981-88-4
- MF:
- C22H34N2O9
- MW:
- 470.51
- Product Categories:
-
- SiChem
- Mol File:
- 2141981-88-4.mol
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TCO4-PEG3-NHS Chemical Properties
- Density
- 1.24±0.1 g/cm3(Predicted)
- solubility
- Soluble in DMSO, DCM, DMF
- pka
- 11.95±0.46(Predicted)
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TCO4-PEG3-NHS Usage And Synthesis
Description
TCO-PEG3-NHS Ester is a PEG linker containing a TCO moiety and a NHS ester. The hydrophilic PEG spacer increases water-solubility and a decreases steric hindrance during ligation. This reagent can be used to label antibodies, proteins and other primary amine-containing macromolecules with TCO moiety.
Uses
TCO-PEG3-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
IC 50
PEGs
References
[1] Wang Y, et al. Degradation of proteins by PROTACs and other strategies. Acta Pharm Sin B. 2020 Feb;10(2):207-238. DOI:10.1016/j.apsb.2019.08.001
TCO4-PEG3-NHSSupplier
Changzhou Hopschain Chemical Co.,Ltd.
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Beijing Jin Ming Biotechnology Co., Ltd.
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Alfa Chemistry
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TargetMol Chemicals Inc.
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Shaanxi Xinyan Bomei Biotechnology Co., Ltd.
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