Fmoc-Aib-OH Chemical Properties

Melting point:

182-188 °C

Boiling point:

544.3±33.0 °C(Predicted)

Density 

1.256±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

pka

3.98±0.10(Predicted)

form 

powder to crystal

color 

White to Almost white

Sensitive 

Moisture Sensitive

BRN 

5604328

Major Application

peptide synthesis

InChI

InChI=1S/C19H19NO4/c1-19(2,17(21)22)20-18(23)24-11-16-14-9-5-3-7-12(14)13-8-4-6-10-15(13)16/h3-10,16H,11H2,1-2H3,(H,20,23)(H,21,22)

InChIKey

HOZZVEPRYYCBTO-UHFFFAOYSA-N

SMILES

C(O)(=O)[C@](C)(C)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O

CAS DataBase Reference

94744-50-0(CAS DataBase Reference)

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

F 

10-21

HazardClass 

IRRITANT

HS Code 

29242990

Storage Class

11 - Combustible Solids

MSDS

• Language:English Provider:SigmaAldrich

Fmoc-Aib-OH Usage And Synthesis

Chemical Properties

Fmoc-Aib-OH is beige powder

Uses

L-Fmoc-Aminobutyric Acid, is an alanine derivative used in chemical synthesis and peptide chemistry.

Uses

Fmoc-Aib-OH is used for studying receptor-ligand interactions using encoded amino acid scanning.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

??-Aminoisobutyric acid was added to a round-bottomed flask, 10% aqueous sodium carbonate was added and stirred to dissolve, then dioxane was added, and a 10% dioxane solution of 9-fluorenylmethoxycarbonyl chloride was slowly added dropwise into the reaction solution under an ice bath, and after the dropwise addition was completed the reaction was carried out in an ice bath for 2 hours, then at room temperature for 8 hours, and the reaction was diluted with the addition of water, and the extraction with ether was carried out 4 times, the aqueous layer was placed in an ice bath, the pH was adjusted with concentrated hydrochloric acid until the Congo red paper showed blue, placed in a refrigerator overnight, the white precipitate was extracted with ethyl acetate, the combined organic solution was washed with water, the organic layer was dried with anhydrous magnesium sulfate, and drained to obtain the product Fmoc-2-aminoisobutyric acid.

Fmoc-Aib-OH(94744-50-0)Related Product Information

• Sucrose acetate isobutyrate
• Paraquat dichloride
• Diethylstilbestrol
• Basic Violet 1
• Propionic acid
• OCTYL ISOBUTYRATE
• Isobutyric acid
• Methanol
• Kresoxim-methyl
• Methyl acrylate
• DL-3-Aminoisobutyric acid
• 9-Fluorenylmethyl chloroformate
• Methyl 2-bromo-2-methylpropionate
• 2-Aminoisobutyric Acid
• Fmoc-OSu
• α-Lipoic Acid
• Acetonitrile
• Methyl acetate