3-BUTEN-1-AMINE Chemical Properties

Boiling point:

74-77°C

Density 

0,777 g/cm³

refractive index 

1.4240

Flash point:

74-77°C

form 

solid

pka

9.96±0.10(Predicted)

Water Solubility 

Miscible with water.

Sensitive 

Air Sensitive

BRN 

1735803

InChI

InChI=1S/C4H9N/c1-2-3-4-5/h2H,1,3-5H2

InChIKey

ASVKKRLMJCWVQF-UHFFFAOYSA-N

SMILES

C(N)CC=C

Safety Information

Risk Statements 

11-34

Safety Statements 

16-26-36/37/39-45

RIDADR 

2733

WGK Germany 

WGK 3

HazardClass 

3

PackingGroup 

II

Storage Class

3 - Flammable liquids

Hazard Classifications

Eye Dam. 1
Flam. Liq. 2
Skin Corr. 1B

MSDS

• Language:English Provider:ALFA

3-BUTEN-1-AMINE Usage And Synthesis

Uses

3-Buten-1-amine is an aliphatic terminal amine used for organic synthesis and in proteomics research. Its hydrochloride salt is used to improve the detection of neurodegenerative alzheimer?s disease in ELISA titrations by reducing the background due to non-specific associations of molecules and proteins.

Definition

ChEBI: 3-buten-1-amine is an alkylamine.

Synthesis

Hydrazine hydrate (20.0 g, 0.40 mol) was added to a solution of N-(3-buten-1-yl)phthalimide (40.2 g, 0.20 mol) in ethanol (200 mL). The reaction solution was heated to reflux for about 1.5 h. The reaction solution was cooled, 40 mL of concentrated hydrochloric acid was added dropwise and filtered after stirring for 10 min. The filtrate was adjusted to pH 7-8 with 5M potassium hydroxide aqueous solution, filtered, the filtrate was extracted with methyl tert-butyl ether (100mL*4), the organic phases were combined, dried with anhydrous potassium carbonate, filtered, and the solvent was removed by evaporation under reduced pressure to give 11.5 g of a white solid, i.e., 3-buten-1-amine.

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