ETHYL 2-CHLORO-4-METHYLPYRIMIDINE-5-CARBOXYLATE Chemical Properties

Boiling point:

302.7±22.0 °C(Predicted)

Density 

1.265

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

solid

pka

-2.56±0.29(Predicted)

color 

white

Water Solubility 

Slightly soluble in water.

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

HS Code 

29335990

ETHYL 2-CHLORO-4-METHYLPYRIMIDINE-5-CARBOXYLATE Usage And Synthesis

Chemical Properties

White solid

Uses

It is an active pharmaceutical intermediates.

Synthesis

The general procedure for the synthesis of ethyl 4-methyl-2-chloropyrimidine-5-carboxylate from ethyl 4-methyl-2-hydroxypyrimidine-5-carboxylate was as follows: ethyl 4-methyl-2-hydroxypyrimidine-5-carboxylate (10 mmol) was dissolved in phosphorochloride (10 mL), and heated and refluxed for 30 min. Upon completion of the reaction, the excess phosphorus trichloride was removed by distillation under reduced pressure. Subsequently, residual phosphorous trichloride was removed by azeotropic distillation with dried benzene. Finally, the crude product was purified by column chromatography to afford pure ethyl 4-methyl-2-chloropyrimidine-5-carboxylate.

References

[1] European Journal of Medicinal Chemistry, 2011, vol. 46, # 6, p. 2290 - 2294
[2] Patent: WO2016/37578, 2016, A1. Location in patent: Page/Page column 70
[3] European Journal of Medicinal Chemistry, 2013, vol. 66, p. 314 - 323

ETHYL 2-CHLORO-4-METHYLPYRIMIDINE-5-CARBOXYLATE(188781-08-0)Related Product Information

• Ethyl (triphenylphosphoranylidene)acetate
• 3-(4-BROMO-PHENYL)-PROPIONIC ACID ETHYL ESTER
• ETHYL-D5 CARBAMATE
• Ectoine
• 4-Hydroxy-2-(trifluoromethyl)pyrimidine
• 4-methyl-2-hydroxy-pyrimidine-5-carboxylic acid
• ETHYL 2-CHLORO-4-PHENYLPYRIMIDINE-5-CARBOXYLATE
• ETHYL 2-HYDROXY-4-PHENYLPYRIMIDINE-5-CARBOXYLATE
• Ethyl 2-hydroxy-4-methyl-5-pyrimidinecarboxylate
• 2-Chloropyrimidine-5-carboxylic acid
• 2-Chloro-4-methylpyrimidine