2,4,6-Trimethylphenol Chemical Properties

Melting point:

70-72 °C(lit.)

Boiling point:

220 °C(lit.)

Density 

0.9809 (estimate)

vapor pressure 

3.86Pa at 25℃

FEMA 

4329 | 2,4,6-TRIMETHYLPHENOL

refractive index 

1.5148 (estimate)

Flash point:

220-221°C

storage temp. 

under inert gas (argon)

form 

Crystalline Needles

pka

pK1:10.88 (25°C)

color 

Beige

Odor

at 0.10 % in propylene glycol. mild phenolic coffee grounds

Odor Type

phenolic

Water Solubility 

1.008g/L(25 ºC)

JECFA Number

2013

BRN 

1859675

LogP

2.73 at 25℃

CAS DataBase Reference

527-60-6(CAS DataBase Reference)

NIST Chemistry Reference

Phenol, 2,4,6-trimethyl-(527-60-6)

EPA Substance Registry System

2,4,6-Trimethylphenol (527-60-6)

Safety Information

Hazard Codes 

C,N

Risk Statements 

34-51/53

Safety Statements 

26-36/37/39-45-24/25-61

RIDADR 

UN 2430 8/PG 3

WGK Germany 

2

RTECS 

OX6590000

TSCA 

Yes

HazardClass 

8

PackingGroup 

III

HS Code 

29071990

Hazardous Substances Data

527-60-6(Hazardous Substances Data)

MSDS

• Language:English Provider:2,4,6-Trimethylphenol
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2,4,6-Trimethylphenol Usage And Synthesis

Chemical Properties

BEIGE CRYSTALLINE NEEDLES

Production Methods

2,4,6-Trimethylphenol is the main product (more than 80%) of the gas phase alkylation of phenol with excess methanol (molar ratio 1 : 5) at 450 ℃ on magnesium oxide catalysts, which are doped with alkali or other metal oxides (e.g., V2O5, SrO). 2,6-Xylenol and 2,3,4,6-tetramethylphenol are the main byproducts.

Synthesis Reference(s)

Journal of the American Chemical Society, 107, p. 1060, 1985 DOI: 10.1021/ja00290a053
Synthetic Communications, 18, p. 1207, 1988 DOI: 10.1080/00397918808060912

Flammability and Explosibility

Not classified

Purification Methods

Crystallise the phenol from water and sublime it in vacuo. [Beilstein 6 IV 3253.]

2,4,6-Trimethylphenol(527-60-6)Related Product Information

• 2,4,6-Tri-tert-butylphenol
• Mordant Blue 3
• GALVINOXYL
• 2-tert-Butyl-4,6-dimethylphenol
• 2,4,6-Trimethylphenol
• SULFORHODAMINE 101
• Thymolphthalein Complexone
• 3,5-Di-tert-butyl-4-hydroxybenzyl alcohol
• (+)-Usniacin
• 4-Hydroxy-3,5-dimethylbenzoic acid
• 4,4'-Methylenebis(2,6-di-tert-butylphenol)
• 3,5-Dimethyl-4-hydroxybenzaldehyde
• 3,5-DIISOPROPYLSALICYLIC ACID
• XYLENOL ORANGE
• METHYL 3,5-DI-TERT-BUTYL-4-HYDROXYBENZOATE
• Butylated Hydroxytoluene
• 2,6-Bis(hydroxymethyl)-p-cresol
• 3,5-Di-tert-butyl-4-hydroxybenzoic acid