PYRIDIN-3-YLMETHYL-HYDRAZINE Chemical Properties

Boiling point:

310℃

Density 

1.104

Flash point:

141℃

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

Appearance

Colorless to light yellow Liquid

PYRIDIN-3-YLMETHYL-HYDRAZINE Usage And Synthesis

Synthesis

General procedure for the synthesis of pyridine-3-methylidenehydrazine (1-(3-pyridyl)methylhydrazine) from 3-pyridinecarboxaldehyde: Hydrazine (1.05 mL, 46.7 mmol) was slowly added to a solution of methanol (100 mL) containing 3-pyridinecarboxaldehyde (5 g, 46.7 mmol). The reaction mixture was stirred continuously for 1 hour at room temperature. Subsequently, the air in the reaction system was replaced with nitrogen and 10% Pd/C catalyst (200 mg) was added. The nitrogen was again replaced with hydrogen and the reaction mixture was stirred overnight at room temperature under hydrogen atmosphere. Upon completion of the reaction, the solid catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to give the crude product pyridine-3-methylenehydrazine (Example 85A). This crude product can be used directly in the subsequent reaction without further purification. Yield: 5.2 g (91% yield). Mass spectrometry (DCI) analysis result: m/z 124 ([M+H]+).

References

[1] Patent: WO2007/95628, 2007, A1. Location in patent: Page/Page column 69-70

PYRIDIN-3-YLMETHYL-HYDRAZINE(7112-38-1)Related Product Information

• 4-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXYLIC ACID HYDRAZIDE
• NICOTINIC ACID HYDRAZIDE
• 5-BROMOPYRIDINE-3-CARBOHYDRAZIDE
• 6-Chloropyridine-3-carbohydrazide
• 2-PHENOXYPYRIDINE-3-CARBOHYDRAZIDE
• 2-(DIMETHYLAMINO)-1H-CHROMENO[2,3-B][1,6]NAPHTHYRIDINE-1,11(2H)-DIONE
• N-((3-CHLORO-5-(TRIFLUOROMETHYL)(2-PYRIDYL))METHYLAMINO)-3-PYRIDYLFORMAMIDE
• N'-[(6-CHLOROPYRIDIN-3-YL)CARBONYL]-4-(TRIFLUOROMETHYL)BENZOHYDRAZIDE
• 1-(4-FLUOROPHENYL)-1,2-DIHYDRO-3H-PYRAZOLO[3,4-B]PYRIDIN-3-ONE
• 1-(4-CHLOROPHENYL)-1,2-DIHYDRO-3H-PYRAZOLO[3,4-B]PYRIDIN-3-ONE
• N-(4-CHLOROPHENYL)-2-[5-(TRIFLUOROMETHYL)THIENO[3,2-B]PYRIDINE-6-CARBONYL]HYDRAZINECARBOTHIOAMIDE
• 1-(3-CHLOROPHENYL)-1,2-DIHYDRO-3H-PYRAZOLO[3,4-B]PYRIDIN-3-ONE
• N'3-([6-CHLORO-4-(TRIFLUOROMETHYL)-3-PYRIDYL]CARBONYL)-6-CHLORO-4-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOHYDRAZIDE
• N'3-(2-PYRIDYL)-6-BROMO-2-CHLOROQUINOLINE-3-CARBOHYDRAZIDE
• N'3-[(6-CHLORO-3-PYRIDYL)CARBONYL]-4-(2-[(4-CHLOROPHENOXY)METHYL]-1,3-THIAZOL-4-YL)-5-METHYLISOXAZOLE-3-CARBOHYDRAZIDE
• 2-CHLORO-N'-[(6-CHLOROPYRIDIN-3-YL)CARBONYL]BENZOHYDRAZIDE
• N'4-[(6-CHLORO-3-PYRIDYL)CARBONYL]-2-CHLORO-6-METHYLPYRIMIDINE-4-CARBOHYDRAZIDE
• 2-(4-CHLOROBENZYL)-1-PHENYL-1,2-DIHYDRO-3H-PYRAZOLO[3,4-B]PYRIDIN-3-ONE