3,5-Dichloroanisole Chemical Properties

Melting point:

39-41 °C (dec.) (lit.)

Boiling point:

97°C 7,6mm

Density 

1.289±0.06 g/cm3(Predicted)

Flash point:

223 °F

storage temp. 

Refrigerator

solubility 

Chloroform, Ethyl Acetate (Slightly), Methanol (Slightly)

form 

Solid

color 

White to Off-White

BRN 

1936395

InChI

1S/C7H6Cl2O/c1-10-7-3-5(8)2-6(9)4-7/h2-4H,1H3

InChIKey

SSNXYMVLSOMJLU-UHFFFAOYSA-N

SMILES

COc1cc(Cl)cc(Cl)c1

CAS DataBase Reference

33719-74-3(CAS DataBase Reference)

NIST Chemistry Reference

Benzene, 3,5-dichloro-1-methoxy-(33719-74-3)

Safety Information

Hazard Codes 

Xn

Risk Statements 

36/37/38-20/22

Safety Statements 

22-24/25-37/39-26

WGK Germany 

3

HS Code 

29093090

Storage Class

11 - Combustible Solids

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

3,5-Dichloroanisole Usage And Synthesis

Chemical Properties

Whitetoyellowcrystalpowde

Uses

3,5-Dichloroanisole, is a chlorinated anisole derivative, possessing possible antibacterial activity. It is also an organic building block that can be used for the synthesis of chlorinated chemical compounds, such as polychlorinated dibenzofurans (PCDD/F).

General Description

3,5-Dichloroanisole on nitration under mild conditions yields 3,5-dichloro-2,4,6-trinitroanisole. The ³⁵Cl Nuclear Quadrupole Resonance (NQR) frequency and spin lattice relaxation time in 3,5-dichloroanisole has been measured.

Synthesis

Under the protection of nitrogen, 2L reaction flask was added 1,3,5-trichlorobenzene 254.1 g (1.4 mol), sodium methanol 151.2 g (2.8 mol, 30% methanol solution), heating to 65 ~ 75 ??, holding, tracking the reaction detection until the reaction is complete, filtration, 400 g of dichloromethane extraction, washed with water to neutral, drying, stripping off the solvent to get 3,5-dichloroanisole Crude product, plus spiked fractionation column for distillation, to get the main fraction 229.1 g, yield 93%, GC: 92%.

3,5-Dichloroanisole(33719-74-3)Related Product Information

• 3,5-Dichlorobenzoic acid
• Guaiacol
• Dichloroethane
• Anisole
• 3,5-Dimethylanisole
• 3,5-Difluoroanisole
• Thionyl chloride
• 2-Chloroanisole
• 4-Methoxyphenol
• 1,3-Dichloropropene
• 2,5-Dichlorobenzoic acid
• 2,3,5,6-TETRACHLOROANISOLE
• 2,3,4,5-TETRACHLOROANISOLE
• 2-(3,5-DICHLOROPHENOXY)ETHANETHIOAMIDE
• L-PYROGLUTAMIC ACID PENTACHLOROPHENYL ESTER
• PENTACHLOROPHENOL DODECANOATE
• 2,3-DICHLOROANISOLE PESTANAL
• 2-(3,5-DICHLOROPHENOXY)ACETONITRILE