Marstacimab
Marstacimab Basic information
- Product Name:
- Marstacimab
- Synonyms:
-
- Marstacimab
- Research Grade Marstacimab(DHC82803)
- Research Grade Marstacimab
- Marstacimab (anti-TFPI)
- CAS:
- 1985638-39-8
- MW:
- 0
- Mol File:
- Mol File
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Marstacimab Chemical Properties
- form
- Liquid
- color
- Colorless to light yellow
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Marstacimab Usage And Synthesis
Uses
Marstacimab (PF-06741086) is an anti-tissue factor pathway inhibitor (TFPI) monoclonal antibody. Marstacimab can be used for the research of hemophilia[1][2].
in vivo
Marstacimab (0.5 mg/kg; i.v., once) does not affect the blood flow situation in mouse acute bleeding models[2].
| Animal Model: | Acute bleeding hemophilia A mouse models[2] |
| Dosage: | 0.5 mg/kg |
| Administration: | Intravenous injection, 0.5 mg/kg, once, before tail clip |
| Result: | Showed no effect on the blood loss compared with control mice, but significantly reduced the blood loss with the combination of aPCC 200 U/kg. |
References
[1] Patel-Hett S, et al. Marstacimab, a tissue factor pathway inhibitor neutralizing antibody, improves coagulation parameters of ex vivo dosed haemophilic blood and plasmas. Haemophilia. 2019 Sep;25(5):797-806. DOI:10.1111/hae.13820
[2] Pittman DD, et al. Hemostatic efficacy of marstacimab alone or in combination with bypassing agents in hemophilia plasmas and a mouse bleeding model. Res Pract Thromb Haemost. 2022 Mar 16;6(2):e12679. DOI:10.1002/rth2.12679
MarstacimabSupplier
Shanghai YuanYe Biotechnology Co., Ltd.
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ShangHai Biochempartner Co.,Ltd
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Guangzhou Hongyuan Chemical Co.,Ltd
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TargetMol Chemicals Inc.
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