3-AMINO-3-METHYL-BUTAN-1-OL Chemical Properties

Boiling point:

71 °C(Press: 9 Torr)

Density 

0.8380 g/cm3

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

15.42±0.10(Predicted)

Appearance

Colorless to light yellow Liquid

Safety Information

RIDADR 

2735

HazardClass 

8

PackingGroup 

Ⅲ

3-AMINO-3-METHYL-BUTAN-1-OL Usage And Synthesis

Uses

3-Amino-3-methylbut-1-ol can be used as a pharmaceutical synthesis intermediate.

Synthesis

Step 3 Synthesis of 3-amino-3-methyl-1-butanol: 3-benzylamino-3-methyl-1-butanol (3.86 g, 20.0 mmol) was dissolved in ethanol (80 mL) and 10% palladium carbon catalyst (400 mg) was added. The reaction mixture was stirred for 6 hours at room temperature under hydrogen atmosphere (5 kgf/cm2). Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under vacuum. The residue was purified by distillation to afford the colorless oily product 3-amino-3-methyl-1-butanol (2.00 g, 97% yield). The structure of the product was confirmed by 1H-NMR (400 MHz, CDCl3): δ1.21 (6H, s), 1.59 (2H, t, J=5.5 Hz), 2.63-2.76 (3H, br), 3.85 (2H, t, J=5.5 Hz).

References

[1] Patent: US2007/254866, 2007, A1. Location in patent: Page/Page column 102

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