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(S)-(+)-2-Amino-3-methyl-1-butanol

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(S)-(+)-2-Amino-3-methyl-1-butanol Basic information

Product Name:
(S)-(+)-2-Amino-3-methyl-1-butanol
Synonyms:
  • L-VALINAL
  • (+)-L-VALINOL
  • L-(+)-VALINOL
  • L-VALINOL
  • L-2-AMINO-3-METHYL-1-BUTANOL
  • l-2-amino-3-methylbutan-1-ol
  • H-VALINOL
  • H-VAL-OL
CAS:
2026-48-4
MF:
C5H13NO
MW:
103.16
EINECS:
217-975-5
Product Categories:
  • Pharmaceutical Intermediates
  • Amines
  • blocks
  • Amino Acid Derivatives
  • Valine [Val, V]
  • Amino Alcohols (Chiral)
  • Amino Alcohols
  • Asymmetric Synthesis
  • Chiral Building Blocks
  • Synthetic Organic Chemistry
  • Chiral Compound
  • Amino alcohols
Mol File:
2026-48-4.mol
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(S)-(+)-2-Amino-3-methyl-1-butanol Chemical Properties

Melting point:
30-34 °C
alpha 
16 º (c=10,EtOH)
Boiling point:
81 °C8 mm Hg(lit.)
Density 
0.926 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.4548(lit.)
Flash point:
196 °F
storage temp. 
Store at +2°C to +8°C.
form 
Liquid After Melting
pka
12.82±0.10(Predicted)
color 
Clear slightly yellow
optical activity
[α]25/D +10°, c = 10 in H2O
Water Solubility 
Soluble in water.
Sensitive 
Air Sensitive
BRN 
1719137
InChIKey
NWYYWIJOWOLJNR-RXMQYKEDSA-N
CAS DataBase Reference
2026-48-4(CAS DataBase Reference)
NIST Chemistry Reference
(S)-(+)-2-Amino-3-methyl-1-butanol(2026-48-4)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36-36/37/38
Safety Statements 
26-24/25-36
WGK Germany 
3
10-23
HazardClass 
IRRITANT
HS Code 
29221980

MSDS

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(S)-(+)-2-Amino-3-methyl-1-butanol Usage And Synthesis

Chemical Properties

white to light yellow crystal powde

Purification Methods

Purify S-valinol by vacuum distillation using a short Vigreux column (p 11). Alternatively it is purified by steam distillation. The steam distillate is acidified with HCl; the aqueous layer is collected and evaporated. The residue is dissolved in butan-1-ol, filtered and dry Et2O added to crystallise the hydrochloride salt (hygroscopic), m 113o. The free base can be obtained by suspending the salt in Et2O and adding small volumes of saturated aqueous K2CO3 until effervescence is complete and the mixture is distinctly alkaline. At this stage the aqueous layer should appear as a white sludge. The mixture is heated to boiling and refluxed for 30minutes (more Et2O is added if necessary). Purification of Biochemicals — Amino Acids and Peptides The Et2O layer is decanted off from the white sludge, the sludge is extracted twice with Et2O (by boiling for a few minutes), the combined organic layers are dried (KOH pellets), evaporated and the residue is distilled in a vacuum. [Nagao et al. J Org Chem 55 1148 1990, Beilstein 4 III 805.]

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