Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)
Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate) Basic information
- Product Name:
- Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)
- Synonyms:
-
- 4-hydroxy-7-[(5-hydroxy-7-sulfonatonaphthalen-2-yl)carbamoylamino]naphthalene-2-sulfonate
- AMI-1 - AMI-1 sodium salt
- AMI-1;AMI 1;AMI1
- disodium 4-hydroxy-7-[(5-hydroxy-7-sulfonato-2-naphthyl)carbamoylamino]naphthalene-2-sulfonate
- disodium 4-hydroxy-7-[(5-hydroxy-7-sulfonato-naphthalen-2-yl)carbamoylamino]naphthalene-2-sulfonate
- disodium 4-hydroxy-7-[(5-hydroxy-7-sulfonatonaphthalen-2-yl)carbamoylamino]naphthalene-2-sulfonate
- J acid urea,disodiuM salt 70%
- 7,7'-(carbonyldiimino)bis(4-hydroxy-2-naphthalenesulfonic acid) disodium salt
- CAS:
- 20324-87-2
- MF:
- C21H17N2NaO9S2
- MW:
- 528.48
- EINECS:
- 243-735-4
- Product Categories:
-
- Inhibitors
- Mol File:
- 20324-87-2.mol
Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate) Chemical Properties
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- insoluble in EtOH; insoluble in DMSO; ≥19.1 mg/mL in H2O
- form
- Brown solid.
- color
- Light brown to brown
- EPA Substance Registry System
- 2-Naphthalenesulfonic acid, 7,7'-(carbonyldiimino)bis[4-hydroxy-, disodium salt (20324-87-2)
Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate) Usage And Synthesis
Chemical Properties
Light grey paste. Soluble in water and easily soluble in alkaline solution.
Uses
AMI-1 is a Histone Methyltransferase (HMT) inhibitor.
Biological Activity
potent, cell permeable and specific protein arginine n-methyltransferase 1 (prmt1) inhibitor (ic50 = 8, 8 μm), does not compete for the adomet (s-adenosyl-l-methionine, sam) binding site, blocks peptide substrate binding, hiv-1 rt polymerase inhibitor (ic50 = 5, 0 μm).
in vivo
AMI-1 (0.5 mg; intratumorally; daily; for 7 days) inhibits S180 viability in vivo[4].
?
AMI-1 (0.5 mg; intratumorally; daily; for 7 days) downregulates PRMT5 but does not regulate the expression of PRMT7 in a tumor xenograft model[4].
?
AMI-1 (0.5 mg; intratumorally; daily; for 7 days) decreases the levels of H4R3me2s and H3R8me2s in a tumor xenograft model[4].
| Animal Model: | 6-7 weeks old male Kunming mice (18-22 g), with S180 cells xenograft[4] |
| Dosage: | 0.5 mg |
| Administration: | Intratumorally, daily, for 7 days |
| Result: | Decreased tumor weight. |
IC 50
PRMT1
Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)Supplier
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Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)(20324-87-2)Related Product Information
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