7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one Chemical Properties

Melting point:

173-175 °C(Solv: ethanol (64-17-5))

Boiling point:

507.1±50.0 °C(Predicted)

Density 

1.48±0.1 g/cm3(Predicted)

solubility 

DMSO: Soluble: =10 mg/ml

pka

10.76±0.70(Predicted)

NIST Chemistry Reference

2H-1,4-benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-(o-fluorophenyl)-3-hydroxy-(17617-60-6)

7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one Usage And Synthesis

Uses

3-Hydroxy desalkylflurazepam is a benzodiazepine with potential sedative and anxiolytic effects[1].

References

[1] Biagi GL, et al. Rm values and structure-activity relationship of benzodiazepines. J Med Chem. 1980 Feb;23(2):193-201. DOI:10.1021/jm00176a016
[2] MORTON A. SCHWARTZ  Edward P. Metabolism of flurazepam, a benzodiazepine, in man and dog[J]. Journal of pharmaceutical sciences, 1970, 59 12: 1800-1806. DOI: 10.1002/jps.2600591220

7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one(17617-60-6)Related Product Information

• Triphenylmethyl Chloride
• tert-Butylchlorodiphenylsilane
• 4-Chlorophenyl isocyanate
• 4,4'-DDT
• CHLOROPHOSPHONAZO III
• 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-one
• OXAZEPAM
• 3-HYDROXY-5-PHENYL-1,3-DIHYDRO-BENZO[E][1,4]DIAZEPIN-2-ONE
• Doxefazepam
• N-desalkylflurazepam
• Cinolazepam
• 7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one
• Difluorochloromethane