3-Deazauridine
3-Deazauridine Basic information
- Product Name:
- 3-Deazauridine
- Synonyms:
-
- 4-HYDROXY-1-BETA-D-RIBOFURANOSYL-2[1H]PYRIDONE
- 3-DEAZAURIDINE
- 3-deazuridine
- 4-hydroxy-1-beta-d-ribofuranosyl-2(1h)-pyridinon
- 4-hydroxy-1-beta-d-ribofuranosyl-2(1h)-pyridinone
- 4-hydroxy-1-beta-d-ribofuranosyl-2(1h)-pyridon
- 3-DEAZAURIDINE CRYSTALLINE
- 1-β-D-Ribofuranosyl-4-hydroxy-2-pyridone
- CAS:
- 23205-42-7
- MF:
- C10H13NO6
- MW:
- 243.21
- EINECS:
- 245-488-8
- Product Categories:
-
- Bases & Related Reagents
- Heterocycles
- Intermediates & Fine Chemicals
- Nucleotides
- Pharmaceuticals
- Mol File:
- 23205-42-7.mol
3-Deazauridine Chemical Properties
- Melting point:
- 233-235°C
- Boiling point:
- 569.2±50.0 °C(Predicted)
- Density
- 1.718±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- form
- Solid
- pka
- 4.50±1.00(Predicted)
- color
- White to Pale Beige
- InChI
- InChI=1/C10H13NO6/c12-4-6-8(15)9(16)10(17-6)11-2-1-5(13)3-7(11)14/h1-3,6,8-10,12-13,15-16H,4H2/t6-,8-,9-,10-/s3
- InChIKey
- CBOKZNLSFMZJJA-FNMQVXAUNA-N
- SMILES
- [C@@H]1([C@H](O)[C@H](O)[C@@H](CO)O1)N1C=CC(O)=CC1=O |&1:0,1,3,5,r|
- LogP
- -1.693 (est)
3-Deazauridine Usage And Synthesis
Description
3-Deazauridine is a structural analog of uridine that inhibits the biosynthesis of Cytidine-5'-Triphosphate by competitive inhibition of Cytidine Triphosphate synthetase, which is considered to be the primary mode of action of this nucleoside analog. This compound has been shown to possess in vitro activity against leukemia L1210 tumor cells, Ehrlich ascites tumor cells, Escherichia coli, and Streptococcus faecium. Despite a paucity of clinical attention given to this drug as a single agent, it has generated much enthusiasm as a biological response modulator because of its synergistic effect with several antitumor agents, including Cytosine Arabinoside, 5-aza-2'-deoxycytidine, 5-azacytidine, thymidine and D-galactosamine. However, only the cytosine arabinoside/3-Deazauridine combination has been explored clinically[1-2].
Uses
Antimetabolite antiviral dosing regimen for hepatitis C virus or flaviviridae therapy.
Definition
ChEBI: 3-Deazauridine is a N-glycosyl compound.
References
[1] W J Moriconi, S Taylor, M Slavik. “3-Deazauridine (NSC 126849): an interesting modulator of biochemical response.” Investigational New Drugs 4 1 (1986): 67–84.
[2] W M Shannon, F M Schabel, G Arnett. “3-Deazauridine: inhibition of ribonucleic acid virus-induced cytopathogenic effects in vitro.” Antimicrobial Agents and Chemotherapy 2 3 (1972): 159–63.
3-DeazauridineSupplier
- Tel
- 0371-85513397 +86-18610099868;
- info@granlen.com
- Tel
- 010-82848833 400-666-7788
- jkinfo@jkchemical.com
- Tel
- 021-61259108 18621169109
- market03@meryer.com
- Tel
- 021-50135380
- shchemsky@sina.com
- Tel
- +86057186818502 13588463833
- info@sagechem.com
3-Deazauridine(23205-42-7)Related Product Information
- N-VINYLACETAMIDE 97
- N-Methylolacrylamide
- N,N-Dimethylacrylamide
- 4-DIMETHYLAMINO-1-BUTANOL
- 3-Methylamino-1,2-propanediol
- N-Methyl-N-vinylacetamide
- N-ETHYL ACRYLAMIDE
- N-(HYDROXYMETHYL)ACETAMIDE
- 3-Dimethylaminopropane-1,2-diol
- 1-Methyl-2-pyridone
- 3-Dimethylamino-1-propanol
- N,N-Dimethylallylamine
- 1-PROPYL-2(1H)-PYRIDINONE
- N-(1-ISOPROPOXYETHYL)ACETAMIDE
- ALLYLETHYLAMINE
- 3-Deazauridine
- 3-Acryloylamino-1-propanol solution, 50% in water
- N-hydroxymethyl-N-methylformamide