N-(HYDROXYMETHYL)ACETAMIDE Chemical Properties

Melting point:

48-52 °C

Boiling point:

165.17°C (rough estimate)

Density 

1.14

refractive index 

1.4368 (estimate)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Chloroform (Sparingly, Sonicated), DMSO (Slightly), Methanol (Slightly)

pka

13.28±0.10(Predicted)

form 

Crystalline

color 

White to Off-White

Water Solubility 

Soluble

Sensitive 

Hygroscopic

Merck 

14,4242

BRN 

506226

InChIKey

HWJHZLJIIWOTGZ-UHFFFAOYSA-N

CAS DataBase Reference

625-51-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

22-24/25-36-26

WGK Germany 

3

RTECS 

AC3610000

F 

10

HazardClass 

IRRITANT

HS Code 

2928009090

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

N-(HYDROXYMETHYL)ACETAMIDE Usage And Synthesis

Chemical Properties

white to light yellow crystalline powder

Uses

N-(Hydroxymethyl)acetamide (cas# 625-51-4) is used as a catalyst in the method for manufacturing sol-gel silica particles method for manufacturing coating substrate coated with silica particles.

Uses

Antiseptic, disinfectant especially for surgical instruments.

Purification Methods

Recrystallise it from freshly distilled Me2CO, wash the crystals with dry Et2O and dry them in a vacuum desiccator over P2O5. RF 0.4 on paper chromatography with CHCl3/EtOH (2:8) as solvent and developed with ammoniacal AgNO3. It also crystallises in needles from EtOAc containing a few drops of Me2CO. It is hygroscopic and should be stored under dry conditions. [Bachmann et al. J Am Chem Soc 73 2775 1951, Walter et al. Chem Ber 99 3204 1966, Einhorn & Ladisch Justus Liebigs Ann Chem 343 265 1905, Beilstein 2 IV 405.]

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