Propanoic acid, 3-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]-, 2,2,2-trifluoroacetate (1:1)
Propanoic acid, 3-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]-, 2,2,2-trifluoroacetate (1:1) Basic information
- Product Name:
- Propanoic acid, 3-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]-, 2,2,2-trifluoroacetate (1:1)
- Synonyms:
-
- Propanoic acid, 3-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]-, 2,2,2-trifluoroacetate (1:1)
- 3-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]propanoic acid
- Thalidomide-4-NH-PEG1-COOH (TFA)
- Poma-PEG1-COOH TFA
- CAS:
- 2140807-20-9
- MF:
- C20H20F3N3O9
- MW:
- 503.39
- Mol File:
- 2140807-20-9.mol
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Propanoic acid, 3-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]-, 2,2,2-trifluoroacetate (1:1) Usage And Synthesis
Uses
Thalidomide-4-NH-PEG1-COOH TFA is an E3 Ligase Ligand-Linker Conjugate consisting of Thalidomide (HY-14658) and NH-PEG3-NH-Boc. Thalidomide-4-NH-PEG1-COOH TFA acts as a ligand for Cereblon to recruit CRBN protein. Thalidomide-4-NH-PEG1-COOH TFA is a key intermediate in the synthesis of CRBN-based PROTAC molecules.
IC 50
Cereblon
References
[1] Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53.??[Content Brief] DOI:10.1038/nature13527
Propanoic acid, 3-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]-, 2,2,2-trifluoroacetate (1:1)Supplier
SHANGHAI FDC-CHEMICAL CO.,LTD
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CR Corporation Limited
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Hubei Kele Fine Chemical Co., Ltd
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Wuhan Augda Biotechnology Co., Ltd
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- 15071299552
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Shanghai Huici Pharmaceutical Technology Co., LTD
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- lixing@pharmahuici.com
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Propanoic acid, 3-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]-, 2,2,2-trifluoroacetate (1:1)(2140807-20-9)Related Product Information
- 1H-Isoindole-1,3(2H)-dione, 4-[(3-azidopropyl)amino]-2-(2,6-dioxo-3-piperidinyl)-
- Propanoic acid, 3-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]-, 2,2,2-trifluoroacetate (1:1)
- Pomalidomide-NH-PEG3-azide
- 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-
- 4-((2-(2-(2-azidoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
- Poma-NH-C4-N3
- 4-((6-azidohexyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
- POMALIDOMIDE-PEG2-CO2H
- Pomalidomide-PEG4-CO2H
- Propanoic acid, 3-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]-, 2,2,2-trifluoroacetate (1:1)
- 4-((5-azidopentyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
- Pomalidomide-PEG3-CO2H
- 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-(2-hydroxyethoxy)ethyl]amino]-
- E3 ligase Ligand-Linker Conjugates 50