Pomalidomide-NH-PEG3-azide Chemical Properties

form 

Solid

color 

Light yellow to yellow

Safety Information

HS Code 

2933998090

Pomalidomide-NH-PEG3-azide Usage And Synthesis

Uses

Pomalidomide 4'-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide-based cereblon ligand and a linker. Pomalidomide 4'-PEG3-azide can be used for the synthesis of iRucaparib-TP3 (Compound 3). iRucaparib-TP3 is a highly efficient PARP1?degrader based on Rucaparib by using the PROTAC approach[1]. Pomalidomide 4'-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

Cereblon

storage

Store at -20°C

References

[1] Shuai Wang, et al. Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation. Nat Chem Biol. 2019 Dec;15(12):1223-1231. DOI:10.1038/s41589-019-0379-2

Pomalidomide-NH-PEG3-azide(2271036-46-3)Related Product Information

• Pomalidomide-NH-PEG2-azide
• Pomalidomide-NH-PEG6-azide
• Pomalidomide-PEG4-azide
• Pomalidomide-NH-PEG1-azide
• Pomalidomide-NH-PEG5-azide
• 1H-Isoindole-1,3(2H)-dione, 4-[(3-azidopropyl)amino]-2-(2,6-dioxo-3-piperidinyl)-
• Propanoic acid, 3-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]-, 2,2,2-trifluoroacetate (1:1)
• 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-
• 4-((2-(2-(2-azidoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
• Poma-NH-C4-N3
• 4-((6-azidohexyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
• Propanoic acid, 3-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]-, 2,2,2-trifluoroacetate (1:1)
• POMALIDOMIDE-PEG2-CO2H
• Pomalidomide-PEG4-CO2H
• Propanoic acid, 3-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]-, 2,2,2-trifluoroacetate (1:1)
• 4-((5-azidopentyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
• Pomalidomide-PEG3-CO2H
• 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-(2-hydroxyethoxy)ethyl]amino]-