taraxerol Chemical Properties

Melting point:

282-285°

Boiling point:

490.7±44.0 °C(Predicted)

Density 

1.01±0.1 g/cm3(Predicted)

storage temp. 

4°C, protect from light

solubility 

≥ 40 mg/mL in DMSO

pka

15.19±0.70(Predicted)

form 

Solid

color 

White

Water Solubility 

insoluble in water

Major Application

food and beverages

InChIKey

GGGUGZHBAOMSFJ-GADYQYKKSA-N

SMILES

CC1(C)CC[C@]2(C)CC=C3[C@]4(C)CC[C@@]5([H])C(C)(C)[C@@H](O)CC[C@]5(C)[C@@]4([H])CC[C@@]3(C)[C@]2([H])C1

LogP

11.060 (est)

Safety Information

WGK Germany 

3

Storage Class

11 - Combustible Solids

taraxerol Usage And Synthesis

Chemical Properties

White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Aster tataricus, Bambusa chinensis, and Taraxacum officinale.

Uses

β-Taraxerol has potential application against novel coronavirus SARS-?CoV-?2, in silico approach to assess the inhibitory potential.

Definition

ChEBI: A pentacyclic triterpenoid that is oleanan-3-ol lacking the methyl group at position 14, with an alpha-methyl substituent at position 13 and a double bond between positions 14 and 15.

Synthesis

The use of efficient extraction method of dandelion root in dandelion racemosanol extraction and separation, including the following steps: (1) reflux method of dandelion root to 30% ~ 95% ethanol solution extraction 1 ~ 3 times, each time 1 ~ 3 hours, the extraction conditions preferably 75% of the ethanol solution extraction three times, each time 1 hour; (2) the combined extracts, concentrated under reduced pressure to the no-alcohol flavor, plus ethanol precipitation of polysaccharides, peptides, etc. (3) and then extracted with an equal volume of ethyl acetate or n-butanol for three times, the extract is concentrated to get the extract; (4) the extract is purified by silica gel column chromatography, reversed-phase column chromatography and other methods. Silica gel column chromatography: generally to petroleum ether - ethyl acetate or chloroform - methanol - water mixed solvent system gradient elution, reversed-phase silica gel column chromatography: commonly used C8 or C18, to gradient methanol and water gradient elution to get the compound dandelion Sai alcohol.

in vivo

target

NO | PGE | TNF-α | IL Receptor | NF-kB | TGF-β/Smad | Akt

taraxerol(127-22-0)Related Product Information

• Carboxyatractyloside
• Terrestrosin D
• taraxasteryl acetate
• Terrestrosin K
• dipotassium dihydrogen 15alpha-hydroxy-2beta-[[2-O-isovaleryl-3,4-di-O-sulphonato-beta-D-glucopyranosyl]oxy]kaur-16-ene-18,19-dioate
• roburic acid
• Taraxasterol
• (4aS,6aS,6aR,8aR,12aS,14aS,14bS)-4,4,6a,6a,8a,11,11,14b-octamethyl-2,4 a,5,6,8,9,10,12,12a,13,14,14a-dodecahydro-1H-picen-3-one
• Poricoic acid A(F)
• Madecassic acid
• Madecassoside
• ALLEOSIDE A
• Pachymic acid
• taraxerol acetate
• Dandelion extract