(4aS,6aS,6aR,8aR,12aS,14aS,14bS)-4,4,6a,6a,8a,11,11,14b-octamethyl-2,4 a,5,6,8,9,10,12,12a,13,14,14a-dodecahydro-1H-picen-3-one
(4aS,6aS,6aR,8aR,12aS,14aS,14bS)-4,4,6a,6a,8a,11,11,14b-octamethyl-2,4 a,5,6,8,9,10,12,12a,13,14,14a-dodecahydro-1H-picen-3-one Basic information
- Product Name:
- (4aS,6aS,6aR,8aR,12aS,14aS,14bS)-4,4,6a,6a,8a,11,11,14b-octamethyl-2,4 a,5,6,8,9,10,12,12a,13,14,14a-dodecahydro-1H-picen-3-one
- Synonyms:
-
- (4aS,6aS,6aR,8aR,12aS,14aS,14bS)-4,4,6a,6a,8a,11,11,14b-octamethyl-2,4 a,5,6,8,9,10,12,12a,13,14,14a-dodecahydro-1H-picen-3-one
- D-Friedoolean-14-en-3-one
- Taraxera-14-ene-3-one
- Taraxerone, 98%, from Adenophora tetraphylla(Thunb.)Fisch
- Taraxeron
- 27-Norolean-14-en-3-one,13-methyl-, (13a)-
- Tarxerone
- 27-Norolean-14-en-3-one, 13-methyl-, (13α)-
- CAS:
- 514-07-8
- MF:
- C30H48O
- MW:
- 424.7
- Mol File:
- 514-07-8.mol
(4aS,6aS,6aR,8aR,12aS,14aS,14bS)-4,4,6a,6a,8a,11,11,14b-octamethyl-2,4 a,5,6,8,9,10,12,12a,13,14,14a-dodecahydro-1H-picen-3-one Chemical Properties
- Melting point:
- 241-243 °C
- Boiling point:
- 488.3±44.0 °C(Predicted)
- Density
- 1.01±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- form
- Solid
- color
- White to off-white
- LogP
- 10.480 (est)
(4aS,6aS,6aR,8aR,12aS,14aS,14bS)-4,4,6a,6a,8a,11,11,14b-octamethyl-2,4 a,5,6,8,9,10,12,12a,13,14,14a-dodecahydro-1H-picen-3-one Usage And Synthesis
Chemical Properties
White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from light bamboo leaves and dandelion.
Uses
Taraxerone is isolated from Sedum sarmentosum. Taraxerone enhances effects on alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) activities with EC50 values of 512.42 and 500.16 μM, respectively[1].
Definition
ChEBI: A natural product found in Cupania cinerea.
in vivo
Taraxerone significantly lowers the plasma alcohol and acetaldehyde concentrations in mice. Compare to the control group, the ADH and ALDH expressions in the liver tissues are abruptly increased in the taraxerone-treated groups after ethanol exposure[1]. Taraxerone prevents catalase, superoxide dismutase, and reduces glutathione concentrations from the decrease induced by ethanol administration[1].
References
[1] Sung CK, et al. Taraxerone enhances alcohol oxidation via increases of alcohol dehyderogenase (ADH) and acetaldehyde dehydrogenase (ALDH) activities and gene expressions.Food Chem Toxicol. 2012 Jul;50(7):2508-14. DOI:10.1016/j.fct.2012.04.031
(4aS,6aS,6aR,8aR,12aS,14aS,14bS)-4,4,6a,6a,8a,11,11,14b-octamethyl-2,4 a,5,6,8,9,10,12,12a,13,14,14a-dodecahydro-1H-picen-3-oneSupplier
- Tel
- +86-21-20908456
- sales@BioChemBest.com
- Tel
- 0871-65217109 13211707573;
- y.liu@mail.biobiopha.com
- Tel
- 021-61312847 13636370518
- shyysw007@163.com
- Tel
- +86-028-82633397 18982077548
- cwb1@biopurify.cn
- Tel
- 021-51320588
- tauto@tautobiotech.com
(4aS,6aS,6aR,8aR,12aS,14aS,14bS)-4,4,6a,6a,8a,11,11,14b-octamethyl-2,4 a,5,6,8,9,10,12,12a,13,14,14a-dodecahydro-1H-picen-3-one(514-07-8)Related Product Information
- Terrestrosin D
- dipotassium dihydrogen 15alpha-hydroxy-2beta-[[2-O-isovaleryl-3,4-di-O-sulphonato-beta-D-glucopyranosyl]oxy]kaur-16-ene-18,19-dioate
- Madecassic acid
- taraxasteryl acetate
- Madecassoside
- Taraxasterol
- roburic acid
- Poricoic acid A(F)
- Terrestrosin K
- ALLEOSIDE A
- Carboxyatractyloside
- Pachymic acid
- taraxerol acetate
- taraxerol