CYCLO(-LEU-PRO)
CYCLO(-LEU-PRO) Basic information
- Product Name:
- CYCLO(-LEU-PRO)
- Synonyms:
-
- 2-a)pyrazine-1,4-dione,hexahydro-3-isobutyl-pyrrolo(stereoisomer
- 4-dione,hexahydro-3-(2-methylpropyl)-2-a)pyrazine-(3s-trans)-pyrrolo(
- cyclo-l-leu-l-pro
- gancidinw
- (3S-trans)-hexahydro-3-isobutylpyrrolo[1,2-a]pyrazine-1,4-dione
- (3S,8aS)-2,3,6,7,8,8a-Hexahydro-3-(2-methylpropyl)pyrrolo[1,2-a]pyrazine-1,4-dione
- (3S,8aS)-Octahydro-3-(2-methylpropyl)pyrrolo[1,2-a]pyrazine-1,4-dione
- Cyclo(L-leucyl-L-prolyl-)
- CAS:
- 2873-36-1
- MF:
- C11H18N2O2
- MW:
- 210.27
- EINECS:
- 220-710-6
- Mol File:
- 2873-36-1.mol
CYCLO(-LEU-PRO) Chemical Properties
- Melting point:
- 163-165℃
- Boiling point:
- 427.6±34.0 °C(Predicted)
- Density
- 1.14
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 13.27±0.40(Predicted)
- color
- White to Off-White
CYCLO(-LEU-PRO) Usage And Synthesis
Description
Cyclo(L-Leu-L-Pro) is a diketopiperazine metabolite that has been isolated from various bacterial and fungal species including Streptomyces. It is active against twelve strains of vancomycin-resistant enterococci (VRE) with MIC values of 12.5 μg/ml for E. faecalis strains K-99-34, K-00-184, and K-00-221. It also inhibits growth of K562, HL-60, and U937 leukemia cells in a concentration-dependent manner when used at concentrations of 1-500 μg/ml. Cyclo(L-Leu-L-Pro) also has antifouling activity, inhibiting attachment of B. amphitrite larva with an EC50 value of 0.15 mM.
Chemical Properties
White Solid
Uses
Sorbicillin analog. A bioactive secondary metabolites from terrestrial Streptomyces species TN262.
Definition
ChEBI: A homodetic cyclic peptide composed from leucyl and prolyl residues.
CYCLO(-LEU-PRO)Supplier
- Tel
- 010-82848833 400-666-7788
- jkinfo@jkchemical.com
- Tel
- 21-61263452 13641803416
- ymbetter@glbiochem.com
- Tel
- 021-50135380
- shchemsky@sina.com
- Tel
- 0755-28351685 18503098468
- innosyn@163.com
- Tel
- 400-1647117 15221909166
- product02@bidepharm.com
CYCLO(-LEU-PRO)(2873-36-1)Related Product Information
- gypsetin
- Pyrrolo[1,2-a]pyrazine, octahydro-3-isobutyl- (5CI)
- CYCLO(-GLY-PRO)
- (R)-HEXAHYDROPYRROLO[1,2-A]PYRAZIN-1(2H)-ONE
- HEXAHYDROPYRROLO[1,2-A]PYRAZINE-1,4-DIONE
- (+/-)-1,4-DIAZABICYCLO[4.4.0]DECANE
- CYCLO(-LEU-GLY)
- hexahydropyrrolo[1,2-a]pyrazin-4(1H)-one
- VERRUCULOGEN
- amauromine
- (S)-1,4-DIAZABICYCLO[4.3.0]NONANE
- 3-ISOBUTYL-6-METHYL-2,5-PIPERAZINEDIONE
- CYCLO(-LEU-PRO)