Basic information Safety Supplier Related

CYCLO(-LEU-PRO)

Basic information Safety Supplier Related

CYCLO(-LEU-PRO) Basic information

Product Name:
CYCLO(-LEU-PRO)
Synonyms:
  • 2-a)pyrazine-1,4-dione,hexahydro-3-isobutyl-pyrrolo(stereoisomer
  • 4-dione,hexahydro-3-(2-methylpropyl)-2-a)pyrazine-(3s-trans)-pyrrolo(
  • cyclo-l-leu-l-pro
  • gancidinw
  • (3S-trans)-hexahydro-3-isobutylpyrrolo[1,2-a]pyrazine-1,4-dione
  • (3S,8aS)-2,3,6,7,8,8a-Hexahydro-3-(2-methylpropyl)pyrrolo[1,2-a]pyrazine-1,4-dione
  • (3S,8aS)-Octahydro-3-(2-methylpropyl)pyrrolo[1,2-a]pyrazine-1,4-dione
  • Cyclo(L-leucyl-L-prolyl-)
CAS:
2873-36-1
MF:
C11H18N2O2
MW:
210.27
EINECS:
220-710-6
Mol File:
2873-36-1.mol
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CYCLO(-LEU-PRO) Chemical Properties

Melting point:
163-165℃
Boiling point:
427.6±34.0 °C(Predicted)
Density 
1.14
storage temp. 
Inert atmosphere,2-8°C
solubility 
Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
form 
Solid
pka
13.27±0.40(Predicted)
color 
White to Off-White
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Safety Information

Toxicity
mouse,LD50,intravenous,80mg/kg (80mg/kg),"Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 2, Pg. 1354, 1978.
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CYCLO(-LEU-PRO) Usage And Synthesis

Description

Cyclo(L-Leu-L-Pro) is a diketopiperazine metabolite that has been isolated from various bacterial and fungal species including Streptomyces. It is active against twelve strains of vancomycin-resistant enterococci (VRE) with MIC values of 12.5 μg/ml for E. faecalis strains K-99-34, K-00-184, and K-00-221. It also inhibits growth of K562, HL-60, and U937 leukemia cells in a concentration-dependent manner when used at concentrations of 1-500 μg/ml. Cyclo(L-Leu-L-Pro) also has antifouling activity, inhibiting attachment of B. amphitrite larva with an EC50 value of 0.15 mM.

Chemical Properties

White Solid

Uses

Sorbicillin analog. A bioactive secondary metabolites from terrestrial Streptomyces species TN262.

Definition

ChEBI: A homodetic cyclic peptide composed from leucyl and prolyl residues.

CYCLO(-LEU-PRO)Supplier

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Email
jkinfo@jkchemical.com
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Email
ymbetter@glbiochem.com
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
ShenZhen InnoSyn Biotech Co.,Ltd
Tel
0755-28351685 18503098468
Email
innosyn@163.com
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Email
product02@bidepharm.com