Dihydrochelerythrine Chemical Properties

Melting point:

164-165 °C

Boiling point:

565.9±50.0 °C(Predicted)

Density 

1.291±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO : 50 mg/mL (143.11 mM; Need ultrasonic and warming)

form 

Powder

pka

2.36±0.20(Predicted)

color 

White to off-white

Dihydrochelerythrine Usage And Synthesis

Description

Dihydrochelerythrine is a benzophenanthridine alkaloid that has been found in Bocconia arborea and has diverse biological activities. It is active against S. aureus, S. faecalis, and C. albicans (MIC = 1.87 μg/ml for all). Dihydrochelerythrine inhibits secretion of the hepatitis B virus (HBV) antigens HBsAg and HBeAg from HepG2 2.2.15 cells (IC₅₀s = <0.05 μM for both). It is cytotoxic to HCT8, BGC-823, and A2780 cancer cells (IC₅₀s = 1.4, 0.4, and 3.5 μM, respectively).

Uses

Dihydrochelerythrine is synthesized as a potential G-quadrulpex DNA stabilizing agent. It is used in phamacokinetic study of chelerythrine metabolites in agro-products.

Definition

ChEBI: Dihydrochelerythrine is a benzophenanthridine alkaloid.

Dihydrochelerythrine(6880-91-7)Related Product Information

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