6-Methoxyldihydrochelerythrine chloride
6-Methoxyldihydrochelerythrine chloride Basic information
- Product Name:
- 6-Methoxyldihydrochelerythrine chloride
- Synonyms:
-
- 6-Methoxyldihydrochelerythrine chloride
- Angoline hydrochloride
- 1,2,13-Trimethoxy-12-methyl-12,13-dihydro-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridine hydrochloride
- 1,2,13-Trimethoxy-12-methyl-12,13-dihydro-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridine hydrochloride
- CAS:
- 1071676-04-4
- MF:
- C22H22ClNO5
- MW:
- 415.87
- Mol File:
- 1071676-04-4.mol
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6-Methoxyldihydrochelerythrine chloride Chemical Properties
- Melting point:
- 267-268 °C
- storage temp.
- Store at -20°C
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6-Methoxyldihydrochelerythrine chloride Usage And Synthesis
Uses
Angoline hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline hydrochloride inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation[1].
References
[1] Jiawei Liu, et al. Angoline: a selective IL-6/STAT3 signaling pathway inhibitor isolated from Zanthoxylum nitidum. Phytomedicine. Jul-Aug 2014;21(8-9):1088-91. DOI:10.1016/j.phymed.2014.04.001
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