angoline
angoline Basic information
- Product Name:
- angoline
- Synonyms:
-
- angoline
- 12,13-Dihydro-1,2,13-trimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridine
- 6-Methoxyldihydrochelerythrine
- [1,3]Benzodioxolo[5,6-c]phenanthridine, 12,13-dihydro-1,2,13-trimethoxy-12-methyl-
- phosphorylation,proliferation,STAT3,anticancer,inhibit,Angoline,Inhibitor,STAT,IL-6
- 6-Methoxydihydrocheleryth
- 1,2,13-Trimethoxy-12-methyl-12,13-dihydro-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridine
- Angoline, 10 mM in DMSO
- CAS:
- 21080-31-9
- MF:
- C22H21NO5
- MW:
- 379.41
- Mol File:
- 21080-31-9.mol
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angoline Chemical Properties
- storage temp.
- 4°C, protect from light
- form
- Solid
- color
- White to off-white
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angoline Usage And Synthesis
Description
The empirical formula of this alkaloid should read C21 H21 NO5
Uses
Angoline is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation[1].
Definition
ChEBI: Angoline is a benzophenanthridine alkaloid.
References
[1] Jiawei Liu, et al. Angoline: a selective IL-6/STAT3 signaling pathway inhibitor isolated from Zanthoxylum nitidum. Phytomedicine. Jul-Aug 2014;21(8-9):1088-91. DOI:10.1016/j.phymed.2014.04.001
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