Basic information Safety Supplier Related

Perospirone hydrochloride

Basic information Safety Supplier Related

Perospirone hydrochloride Basic information

Product Name:
Perospirone hydrochloride
Synonyms:
  • PEROSPIRONE HYDROCHLORIDE
  • PEROSPIRONE HYDROCHLORIDE DIHYDRATE
  • PEROSPIRONE HYDROCHLORIDE HYDRATE
  • 1h-isoindole-1,3(2h)-dione,2-(4-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)but
  • monohydrochloride,cis-yl)hexahydro
  • sm-9018
  • (3aR,7aS)-rel-2-[4-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]butyl]hexahydro-1H- isoindole-1,3(2H)-dione Hydrochloride Trihydrate
  • Lulla
CAS:
129273-38-7
MF:
C23H31ClN4O2S
MW:
463.04
Product Categories:
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
129273-38-7.mol
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Perospirone hydrochloride Chemical Properties

Melting point:
95-970C
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
White to Off-White
InChIKey
HIZFAPMOZFYELI-GNXQHMNLNA-N
SMILES
C(N1CCN(C2=NSC3C=CC=CC2=3)CC1)CCCN1C([C@@]2([H])CCCC[C@@]2([H])C1=O)=O.Cl |&1:21,27,r|
CAS DataBase Reference
129273-38-7(CAS DataBase Reference)
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Perospirone hydrochloride Usage And Synthesis

Chemical Properties

White Solid

Uses

Serotonin (5-HT2) and dopamine (D2) antagonist (SDA).

Biological Activity

Perospirone (SM-9018) is a typical neuroleptic (antipsychotic) agent th at displays high affinity for 5-HT2, D2 and 5-HT1A receptors (Ki = 0.61, 1.4 and 2.9-1.8 nM, respectively), moderate affinity for alpha 1 and D1 receptors (Ki = 17 and 41 nM, respectively), while exhibiting much reduced affinity for alpha 2 (Ki = 408 nM) and little affinity toward muscarinic, opiate, glutamate, phencyclidine, benzodiazepine or GABAA receptors (Ki >1 μM). SM-9018 antagonizes both D2-dependent (e.g. methamphetamine-induced hyperactivity, apomorphine-induced stereotypy) and 5-HT2-mediated (e.g. tryptamine-induced clonic seizure) activities in vivo, while exhibiting very low cataleptogenic and central depressant activities commonly observed with two other neuroleptics, haloperidol and chlorpromazine.

IC 50

5-HT2A Receptor: 0.6 nM (Ki); D2 Receptor: 1.4 nM (Ki); 5-HT1A Receptor: 2.9 nM (Ki); 5-HT1 Receptor: 18 nM (Ki); D1 Receptor: 41 nM (Ki)

Perospirone hydrochlorideSupplier

Zhuhai Free Trade Zone Lizhu Synthetic Pharmaceutical Co., Ltd. Gold
Tel
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Email
jkinfo@jkchemical.com
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Email
info@yuhaochemical.com
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Perospirone hydrochloride(129273-38-7)Related Product Information