Perospirone hydrochloride
Perospirone hydrochloride Basic information
- Product Name:
- Perospirone hydrochloride
- Synonyms:
-
- PEROSPIRONE HYDROCHLORIDE
- PEROSPIRONE HYDROCHLORIDE DIHYDRATE
- PEROSPIRONE HYDROCHLORIDE HYDRATE
- 1h-isoindole-1,3(2h)-dione,2-(4-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)but
- monohydrochloride,cis-yl)hexahydro
- sm-9018
- (3aR,7aS)-rel-2-[4-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]butyl]hexahydro-1H- isoindole-1,3(2H)-dione Hydrochloride Trihydrate
- Lulla
- CAS:
- 129273-38-7
- MF:
- C23H31ClN4O2S
- MW:
- 463.04
- Product Categories:
-
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 129273-38-7.mol
Perospirone hydrochloride Chemical Properties
- Melting point:
- 95-970C
- storage temp.
- -20°C Freezer
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- White to Off-White
- CAS DataBase Reference
- 129273-38-7(CAS DataBase Reference)
Perospirone hydrochloride Usage And Synthesis
Chemical Properties
White Solid
Uses
Serotonin (5-HT2) and dopamine (D2) antagonist (SDA).
Biological Activity
Perospirone (SM-9018) is a typical neuroleptic (antipsychotic) agent th at displays high affinity for 5-HT2, D2 and 5-HT1A receptors (Ki = 0.61, 1.4 and 2.9-1.8 nM, respectively), moderate affinity for alpha 1 and D1 receptors (Ki = 17 and 41 nM, respectively), while exhibiting much reduced affinity for alpha 2 (Ki = 408 nM) and little affinity toward muscarinic, opiate, glutamate, phencyclidine, benzodiazepine or GABAA receptors (Ki >1 μM). SM-9018 antagonizes both D2-dependent (e.g. methamphetamine-induced hyperactivity, apomorphine-induced stereotypy) and 5-HT2-mediated (e.g. tryptamine-induced clonic seizure) activities in vivo, while exhibiting very low cataleptogenic and central depressant activities commonly observed with two other neuroleptics, haloperidol and chlorpromazine.
Perospirone hydrochlorideSupplier
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Perospirone hydrochloride(129273-38-7)Related Product Information
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- PEROSPIRONE
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