1-PHENYL-3-(2-THIAZOLYL)-2-THIOUREA
1-PHENYL-3-(2-THIAZOLYL)-2-THIOUREA Basic information
- Product Name:
- 1-PHENYL-3-(2-THIAZOLYL)-2-THIOUREA
- Synonyms:
-
- 1-PHENYL-3-(THIAZOL-2-YL)THIOUREA
- 1-PHENYL-3-(2-THIAZOLYL)-2-THIOUREA
- :1-phenyl-3-(1,3-thiazol-2-yl)thiourea
- 1-phenyl-3-(2-thiazolyl)-2-thio-ure
- n-phenyl-n’-2-thiazolyl-thioure
- phenylthiazolylthiourea
- Urea, 1-phenyl-3-(2-thiazolyl)-2-thio.
- 1-Phenyl-3-(2-thiazolyl)thiourea
- CAS:
- 14901-16-7
- MF:
- C10H9N3S2
- MW:
- 235.33
- EINECS:
- 238-970-4
- Mol File:
- 14901-16-7.mol
1-PHENYL-3-(2-THIAZOLYL)-2-THIOUREA Chemical Properties
- Melting point:
- 183-185 °C (dec.)(lit.)
- Density
- 1.3479 (rough estimate)
- refractive index
- 1.5500 (estimate)
- form
- Solid
- color
- Off-white to yellow
- CAS DataBase Reference
- 14901-16-7(CAS DataBase Reference)
Safety Information
- Hazard Codes
- Xn
- Risk Statements
- 22-37/38-41
- Safety Statements
- 26-39
- WGK Germany
- 3
- RTECS
- YU1398000
MSDS
- Language:English Provider:SigmaAldrich
1-PHENYL-3-(2-THIAZOLYL)-2-THIOUREA Usage And Synthesis
Chemical Properties
light brown fine crystalline powder
Uses
U-14624 is a potent and orally active dopamine beta-hydroxylase inhibitor. U-14624 suppresses the activities of aminopyrine N-demethylase, aniline hydroxylase and p-nitroanisole O-demethylase enzymes[1][2].
in vivo
U-14624 (50 mg/kg; i.p.; daily for 5-7 days) suppresses the activities of aminopyrine N-demethylase, aniline hydroxylase and p-nitroanisole O-demethylase enzymes in rats[2].
| Animal Model: | 150-260 g, Male Sprague-Dawley rats[2] |
| Dosage: | 25 mg/kg |
| Administration: | I.p.; daily for 3 days |
| Result: | Prolonged the time required for clearance of pentobarbital from both the plasma and brain, slept significantly longer. |
| Animal Model: | 150-260 g, Male Sprague-Dawley rats[2] |
| Dosage: | 50 mg/kg |
| Administration: | I.p.; daily for 5-7 days |
| Result: | Suppressed the activities of aminopyrine N-demethylase, aniline hydroxylase and p-nitroanisole O-demethylase enzymes. |
References
[1] Von Voigtlander PF, et al. Behavioral and brain catecholamine depleting actions of U-14,624, an inhibitor of dopamine beta-hydroxylase. Proc Soc Exp Biol Med. 1970 Mar;133(3):817-20. DOI:10.3181/00379727-133-34571
[2] Smith JR, et al. Effect of the catecholamine-depleting agent 1-phenyl-3-(2-thiazolyl)-2-thiourea (U-14,624) on drug metabolism in the rat. Biochem Pharmacol. 1980 Sep 15;29(18):2425-30. DOI:10.1016/0006-2952(80)90345-7
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