Nimustine Chemical Properties

Melting point:

125°C (rough estimate)

Boiling point:

98°C (rough estimate)

Density 

1.9048 (rough estimate)

refractive index 

1.5790 (estimate)

pka

9.58±0.46(Predicted)

form 

solid

CAS DataBase Reference

42471-28-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

T

Risk Statements 

25

Safety Statements 

36/37/39-45

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

3

RTECS 

YR8450000

MSDS

• Language:English Provider:SigmaAldrich

Nimustine Usage And Synthesis

Originator

Nidran,Sankyo,Japan,1979

Definition

ChEBI: An organochlorine compound that is urea in which the two hydrogens on one of the amino groups are replaced by nitroso and 2-chloroethyl groups and one hydrogen from the other amino group is replaced by a 4-amino-2-methylpyrimidin-5-ylmethyl] group. An anti eoplastic agent especially effective against malignant brain tumors.

Manufacturing Process

0.4 g of sodium nitrite was added with stirring, at 0°C to 5°C, to a solution of 450 mg of 1-(2-chloroethyl)-3-[(2-methyl-4-aminopyridin-5-yl)methyl]urea in 8 ml of 5% hydrochloric acid, and the reaction mixture was then stirred at 0°C to 10°C for an additional 1.5 hours.
After completion of the reaction, the reaction mixture was made alkaline by the addition of sodium carbonate, whereupon crystals separated out in situ. The crystals were recovered by filtration, washed with water and then recrystallized from 6 ml of ethanol, to give 0.1 g of the pale yellow pure desired product having a decomposition point of 125°C.

Therapeutic Function

Antitumor, Antileukemic

Nimustine(42471-28-3)Related Product Information

• Ethylurea
• Bendamustine
• Semicarbazide
• Kresoxim-methyl
• Methyl acrylate
• Thiophanate-methyl
• METSULFURON METHYL
• Bensulfuron methyl
• Bendamustine hydrochloride
• Methylparaben
• Methyl acetate
• Methyl
• Methyl bromide
• NIMUSTINE HYDROCHLORIDE,NIMUSTINE HCL
• Parathion-methyl
• 1-Methyl-1-nitrosourea
• N-NITROSO-N-ETHYLUREA
• Chlorine