N-NITROSO-N-ETHYLUREA Chemical Properties

Melting point:

103-1040C (dec)

Boiling point:

182℃

Density 

1.35

refractive index 

1.4900 (estimate)

Flash point:

64℃

storage temp. 

-20°C

solubility 

DMSO (Soluble), Methanol (Sparingly)

form 

Semi-Solid to Low-Melting Solid

pka

12.32±0.50(Predicted)

color 

Off-White to Red

Water Solubility 

12.83g/L(room temperature)

Stability:

Unstable at RT, Contains approximately 40% Water, 2.0% Acetic Acid to stabilize

CAS DataBase Reference

759-73-9(CAS DataBase Reference)

IARC

2A (Vol. 17, Sup 7) 1987

EPA Substance Registry System

N-Nitroso-N-ethylurea (759-73-9)

Safety Information

Hazard Codes 

T

Risk Statements 

45-46-61-20/21/22

Safety Statements 

53-22-36/37/39-45

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

3

RTECS 

YT3150000

HazardClass 

6.1(b)

PackingGroup 

III

Hazardous Substances Data

759-73-9(Hazardous Substances Data)

Toxicity

LD50 i.v. in rats: 240 mg/kg (Druckrey)

MSDS

• Language:English Provider:SigmaAldrich

N-NITROSO-N-ETHYLUREA Usage And Synthesis

Chemical Properties

Orange Paste

Chemical Properties

N-Nitroso-N-ethyl urea is a pale yellow, crystalline powder; freezing/melting point=103－104°C (decomposes). Hazard identification (based on NFPA-704 M Rating System): Health 2; flammability 1; reactivity 0?. Soluble in water; hydrolysis produces explosive gas.

Uses

A precursor of Diazoethane

Uses

N-Nitroso-N-ethylurea has been used as a mutation-inducing agent.

Uses

Experimentally as mutagen; ethylating agent.

Definition

ChEBI: A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by ethyl and nitroso groups.

General Description

Yellow-pink crystals or off-white powder. Sensitive to light.

Air & Water Reactions

Water soluble. Sensitive to moisture--stability in aqueous solutions depends on pH.

Reactivity Profile

N-NITROSO-N-ETHYLUREA is highly reactive. Sensitive to moisture and light. Its stability in aqueous solutions is pH-dependent. Incompatible with water and nucleophilic reagents. Alkaline hydrolysis produces a highly explosive gas. .

Hazard

Tumorigen, carcinogen, neoplastigen; teratogen; poison; toxic.

Health Hazard

ACUTE/CHRONIC HAZARDS: N-NITROSO-N-ETHYLUREA is extremely unstable at high pH. It will decompose to extremely unstable decomposition products if acidic conditions are not maintained. When heated to decomposition it emits toxic fumes of nitrogen oxides. Decomposition products may be explosive.

Fire Hazard

Flash point data for N-NITROSO-N-ETHYLUREA are not available; however, N-NITROSO-N-ETHYLUREA is probably combustible.

Biochem/physiol Actions

DNA alkylating agent that is carcinogenic in many animal species. Induces benign and malignant tumors of numerous types, including the nervous tissue, stomach, esophagus, pancreas, respiratory tract, intestine, lymphoreticular tissues, skin, and kidney.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Poison by ingestion, subcutaneous, intraperitoneal, and intravenous routes. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also N-NITROSO COMPOUNDS.

Potential Exposure

Used as a chemical intermediate for dyes and pharmaceuticals; a polymerization inhibitor during the manufacture of vinyl monomers such as styrene; a precursor of diazoethane; accelerator for rubber vulcanization.

Carcinogenicity

N-Nitroso-N-ethylurea is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

Shipping

Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard Class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required.

Incompatibilities

N-nitroso-N-ethylurea is highly reactive. Sensitive to moisture and light. Its stability in aqueous solutions is pH-dependent. Incompatible with water and nucleophilic reagents. Alkaline hydrolysis produces a highly explosive gas. This compound is extremely unstable at high pH. It will decompose to extremely unstable decomposition products if acidic conditions are not maintained. Nitrated organics range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction. Reaction with

Waste Disposal

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.

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