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Ranimustine

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Ranimustine Basic information

Product Name:
Ranimustine
Synonyms:
  • 1-(2-chloroethyl)-1-nitroso-3-[[(2r,3s,4s,5r,6s)-3,4,5-trihydroxy-6-methoxy-oxan-2-yl]methyl]urea
  • Cymerin
  • MCNU
  • Methyl 6-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]-6-deoxy-α-D-glucopyranoside
  • NSC-0270516
  • Ranomustine
  • Thymerin
  • Methyl 6-[3-(2-chloroethyl)-3-nitrosoureido]-6-deoxy-α-D-glucopyranoside
CAS:
58994-96-0
MF:
C10H18ClN3O7
MW:
327.72
Mol File:
58994-96-0.mol
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Ranimustine Chemical Properties

Melting point:
111-112°
alpha 
D20 +93.2° (c = 0.5 in methanol) (Kimura); D25 +73.2° (c = 0.3 in methanol) (Kimura, Sekine)
Density 
1.69±0.1 g/cm3(Predicted)
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
10.59±0.46(Predicted)
color 
Off-White to Pale Yellow
CAS DataBase Reference
58994-96-0(CAS DataBase Reference)
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Safety Information

Toxicity
LD50 in male rats (mg/kg): 42 i.p., 42 i.v., 50 orally (Kimura)
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Ranimustine Usage And Synthesis

Description

Ranimustine, a new nitrosourea derivative, is a water soluble antitumor agent with low hematological toxicity and diabetogenic effect. It is reportedly effective in the treatment of hematologic malignancies, especially the myeloproliferative disorders.

Originator

Tokyo Tanabe (Japan)

Uses

Glucocorticoid with low systemic absorption anti-inflammatory agent

Definition

ChEBI: Ranimustine is an organic molecular entity.

brand name

Cymerine

Ranimustine Preparation Products And Raw materials

Raw materials

RanimustineSupplier

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