L-Aspartic acid 4-benzyl ester
L-Aspartic acid 4-benzyl ester Basic information
- Product Name:
- L-Aspartic acid 4-benzyl ester
- Synonyms:
-
- H-ASP(OBZL)-OH
- H-L-ASP(OBZL)-OH
- L-ASPARTIC ACID 4-BENZYL ESTER
- L-ASPARTIC ACID BETA-BENZYL ESTER
- ASPARTIC ACID(OBZL)-OH
- BETA-BENZYL L-ASPARTATE
- benzyl hydrogen beta-L-aspartate
- Asp(OBz)-OH
- CAS:
- 2177-63-1
- MF:
- C11H13NO4
- MW:
- 223.23
- EINECS:
- 218-541-8
- Product Categories:
-
- Amino Acids Derivatives
- Aspartic acid [Asp, D]
- Amino Acids and Derivatives
- Amino Acids
- alpha-Amino Acids
- Amino Acid Benzyl Esters
- Amino Acids (C-Protected)
- Biochemistry
- AMINOACIDS DERIVATIVES
- Mol File:
- 2177-63-1.mol
L-Aspartic acid 4-benzyl ester Chemical Properties
- Melting point:
- ~225 °C (dec.)
- Boiling point:
- 413.1±45.0 °C(Predicted)
- Density
- 1.283±0.06 g/cm3(Predicted)
- refractive index
- 27 ° (C=1, 1mol/L HCl)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- pka
- 2.16±0.23(Predicted)
- form
- Powder
- color
- White
- Water Solubility
- Insoluble in water.
- BRN
- 1983183
- CAS DataBase Reference
- 2177-63-1(CAS DataBase Reference)
Safety Information
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- HS Code
- 29242990
MSDS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ALFA
L-Aspartic acid 4-benzyl ester Usage And Synthesis
Chemical Properties
Crystalline
Uses
L-Aspartic acid β-benzyl ester is used in the synthesis of peptides with a 1,4-diazepine-2,5-dione ring structure and in development of block copolymers.
Definition
ChEBI: L-aspartic acid beta-benzyl ester is an aspartic acid derivative.
Synthesis
56-84-8
100-51-6
2177-63-1
100 mL of anhydrous ether was added to a 500 mL beaker and 20 mL of concentrated sulfuric acid was added slowly and dropwise while stirring and cooling to room temperature. Subsequently, 150 mL of benzyl alcohol was added and the ether was removed by stirring well. Under reduced pressure, 26 g of L-aspartic acid was added to the reaction flask in 5 batches. The reaction was stirred for 24 h at room temperature, after which 300 mL of 95% ethanol was added, and 80 mL of pyridine was slowly added dropwise through a dropping funnel with vigorous stirring while dropping. The reaction mixture was placed in a refrigerator overnight and the solid was collected by filtration. The solid was dissolved with 80% ethanol with stirring, heated and filtered. The filtrate was frozen for 8 hours, filtered again and finally lyophilized to obtain pure β-aspartic acid benzyl ester in 90% yield.
References
[1] Journal of Natural Products, 2017, vol. 80, # 7, p. 2136 - 2140
[2] Patent: CN107129501, 2017, A. Location in patent: Paragraph 0009; 0010; 0011
[3] Synthesis and Reactivity in Inorganic, Metal-Organic and Nano-Metal Chemistry, 2011, vol. 41, # 5, p. 459 - 464
[4] Patent: US2004/133033, 2004, A1. Location in patent: Page 4-5
[5] Chemistry - A European Journal, 2018, vol. 24, # 54, p. 14373 - 14377
L-Aspartic acid 4-benzyl esterSupplier
- Tel
- 18210857532; 18210857532
- jkinfo@jkchemical.com
- Tel
- 4006356688 18621169109
- market03@meryer.com
- Tel
- 400-0066400 13621662912
- sales@jonln.com
- Tel
- 400-6106006
- saleschina@alfa-asia.com
- Tel
- 021-67121386
- Sales-CN@TCIchemicals.com
L-Aspartic acid 4-benzyl ester(2177-63-1)Related Product Information
- L-Aspartic acid dibenzyl ester 4-toluenesulfonate
- L-ASPARTIC ACID
- Methyl acrylate
- Benzyl benzoate
- Benzyl bromide
- Tris(trimethylsilyl)phosphate
- Benzyl alcohol
- Poly-L-aspartic acid
- L-Aspartic acid
- Sodium L-aspartate
- H-Asp(OAll)-OH.HCl
- H-ASP(OBZL)-OBZL HCL
- H-ASP(OBZL)-NH2 HCL
- N-Cbz-L-Aspartic acid 4-benzyl ester
- BOC-ASP(OBZL)-OSU
- FMOC-ASP(O-2-PHIPR)-OH
- Fmoc-L-Aspartic acid-1-benzyl ester
- Boc-L-aspartic acid 4-benzyl ester