L-Glutamic acid, N-[N-[N-[N-[4-[[(2, 4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-.gamma.-gluta myl]-L-.gamma.-glutamyl]-L-.gamma.-glutamyl]- Chemical Properties

Melting point:

>123°C (dec.)

Density 

1.541±0.06 g/cm3(Predicted)

storage temp. 

Hygroscopic, -20°C Freezer, Under inert atmosphere

solubility 

DMSO (Slightly), Methanol(Slightly)

form 

Solid

pka

3.39±0.10(Predicted)

color 

Light Yellow to Orange

Stability:

Hygroscopic

L-Glutamic acid, N-[N-[N-[N-[4-[[(2, 4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-.gamma.-gluta myl]-L-.gamma.-glutamyl]-L-.gamma.-glutamyl]- Usage And Synthesis

Uses

Methotrexate Tetraglutamate is a metabolite of Methotrexate (M260675); a folic acid antagonist, antineoplastic, and antirheumatic.

L-Glutamic acid, N-[N-[N-[N-[4-[[(2, 4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-.gamma.-gluta myl]-L-.gamma.-glutamyl]-L-.gamma.-glutamyl]-(73610-81-8)Related Product Information

• METHOTREXATE DIMETHYL ESTER
• Methotrexate Related Compound E (50 mg) (4-{[(2,4-Diaminopteridin-6-yl)methyl](methyl)amino}benzoic acid, hemihydrochloride)
• 2,4-DIAMINO-6-(HYDROXYMETHYL)PTERIDINE
• 7-HYDROXY METHOTREXATE
• D(-)-AMETHOPTERIN
• Methotrexate γ-Methyl Ester
• Folic Acid Related Compound A/Calcium Formyltetrahydrofolate
• methotrexate-gamma-dimethylamide
• Methotrexate impurity
• 4-[N-(2,4-DIAMINO-6-PTERIDINYLMETHYL)-N-METHYLAMINO] BENZOIC ACID
• N-(4-(METHYLAMINO)BENZOYL)-L-GLUTAMIC ACID
• L-Glutamic acid, N-(N-(4-(((2,4-diamino-6-pteridinyl)methyl)methyl-
• L-Glutamic acid der.
• Aminopterin
• METHOTREXATE-D3
• Methotrexate α-Methyl Ester
• L-Glutamic acid, N-[4-[[ (2-amino-1, 4-dihydro-4-oxo-6-pteridinyl)meth yl]methylamino]benzoyl]-
• 4-[Methyl[(2-amino-4-hydroxypteridine)-6-ylmethyl]amino]benzoic acid