NALPHA-FMOC-L-SERINE TERT-BUTYL ESTER Chemical Properties

Melting point:

127 °C

Boiling point:

588.4±45.0 °C(Predicted)

Density 

1.216±0.06 g/cm3(Predicted)

refractive index 

11 ° (C=1, CHCl3)

storage temp. 

Sealed in dry,2-8°C

solubility 

soluble in Chloroform

form 

powder to crystal

pka

10.07±0.46(Predicted)

color 

White to Orange to Green

InChIKey

ZYOWIDHANLLHNO-IBGZPJMESA-N

Safety Information

HS Code 

2924.19.8000

NALPHA-FMOC-L-SERINE TERT-BUTYL ESTER Usage And Synthesis

Uses

Fmoc-Ser-OtBu is a serine derivative[1].

Synthesis

L-serine tert-butyl ester was added to a round-bottomed flask, 10% aqueous sodium carbonate was added and stirred to dissolve, then dioxane was added, and a 10% dioxane solution of 9-fluorenylmethoxycarbonyl chloride was slowly added dropwise into the reaction solution under an ice bath, and after the dropwise addition was completed the reaction was carried out for 2 hrs in an ice bath, and then at room temperature for 8 hrs, and the reaction was diluted with the addition of water, and the extract was carried out with ether 4 times, the aqueous layer was placed in an ice bath, the pH was adjusted with concentrated hydrochloric acid until the Congo red paper showed blue, placed in a refrigerator overnight, the white precipitate was extracted with ethyl acetate, the combined organic solution was washed with water, the organic layer was dried with anhydrous magnesium sulfate, and pumped dry to get the product tert-butyl N-(9-fluorenylmethoxycarbonyl)-L-serinate.

References

[1] Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144. DOI:10.1080/10408398.2012.708368

NALPHA-FMOC-L-SERINE TERT-BUTYL ESTER(110797-35-8)Related Product Information

• Fmoc-N-(propyl)-glycine
• 4-(FMOC-AMINO)-TETRAHYDROPYRAN-4-CARBOXYLIC ACID
• Fmoc-Thr(Allyl)-OH
• FMOC-SER(GALNAC(AC)3-ALPHA-D)-OH
• FMOC-THR(GALNAC(AC)3-ALPHA-D)-OH
• BOC-D-PRO-OSU
• Fmoc-O-trityl-L-threonine
• Fmoc-N-(2,4,6-trimethoxybenzyl)-glycine
• (4S)-3-(FMoc-Thr(tBu))-2,2-diMethyl-oxazolidine-4-carboxylic acid
• Fmoc-Trp(Boc)-OH
• N-Fmoc-6-Methoxy-L-tryptophan
• Fmoc-O-trityl-L-serine
• Fmoc-(S)-2-amino-6-phenylhexanoic acid
• Fmoc-Trp(N-CH2COOAll)-OH
• FMOC-SER(TBU)-SER(PSIME,MEPRO)-OH
• D-Serine, O-ethyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
• Fmoc-Ser(Allyl)-OH
• NALPHA-FMOC-L-THREONINE TERT-BUTYL ESTER