1-Lauryl-2-pyrrolidone Chemical Properties

Melting point:

4°C

Boiling point:

202-205 °C11 mm Hg(lit.)

Density 

0.89 g/mL at 25 °C(lit.)

vapor pressure 

0.002Pa at 25℃

refractive index 

n20/D 1.466(lit.)

Flash point:

>230 °F

storage temp. 

Sealed in dry,Room Temperature

form 

viscous liquid

pka

-0.43±0.20(Predicted)

Appearance

Colorless to light yellow Liquid

Water Solubility 

51.7mg/L at 20℃

InChIKey

NJPQAIBZIHNJDO-UHFFFAOYSA-N

LogP

4.03 at 21℃

CAS DataBase Reference

2687-96-9(CAS DataBase Reference)

EPA Substance Registry System

N-Lauryl-2-pyrrolidone (2687-96-9)

Safety Information

Hazard Codes 

C,N

Risk Statements 

34-43-50/53

Safety Statements 

26-36/37/39-45-60-61

RIDADR 

UN 3267 8/PG 3

WGK Germany 

2

RTECS 

UY5768000

HazardClass 

8

PackingGroup 

III

MSDS

• Language:English Provider:SigmaAldrich

1-Lauryl-2-pyrrolidone Usage And Synthesis

Chemical Properties

Colorless transparent liquid

Uses

1-Dodecyl-2-pyrrolidinone was used in the preparation of few-layered flakes of molybdenum disulfide (MoS₂) via liquid phase exfoliation of bulk MoS₂ powder.

Definition

ChEBI: 1-dodecylpyrrolidin-2-one is pyrrolidin-2-one substituted at nitrogen by an n-dodecyl group. It has a role as an epitope.

General Description

1-Dodecyl-2-pyrrolidinone is an N-alkyl lactam and its reduction with LiH₃BNMe₂ to the corresponding amine has been reported. It is a potential melatonin-specific chemical penetration enhancer.

Flammability and Explosibility

Non flammable

Synthesis

Step A: Tetrabutylammonium bromide (950 mg, 3 mmol, 0.05 eq.) and powdered potassium hydroxide (23.1 g, 411 mmol, 7 eq.) were sequentially added to a toluene (60 mL) solution of 2-pyrrolidone (5.00 g, 58.8 mmol) under stirring conditions. Subsequently, a toluene solution of bromododecane (18.5 mL, 76.4 mmol, 1.3 eq.) was added to the mixture. The reaction mixture was heated to 50 °C and stirred at this temperature overnight. The progress of the reaction was monitored by thin layer chromatography (TLC) using a solvent mixture of ethyl acetate and cyclohexane (4:1, v/v) as the unfolding agent and phosphomolybdic acid as the color developer until the complete disappearance of 2-pyrrolidone. After completion of the reaction, the mixture was cooled to room temperature, 60 mL of water was added and stirring was continued for 15 min. The aqueous and organic phases were separated and the aqueous phase was extracted once with diethyl ether (60 mL). The organic phase was combined, dried with anhydrous sodium sulfate, filtered and concentrated. The product was purified by vacuum distillation (146 °C, 0.5 mbar) to afford N-dodecylpyrrolidin-2-one in 80% yield. The structure of the product was characterized by 1H NMR and 13C NMR: 1H NMR (400 MHz, CDCl3) δ (ppm): 0.88 (t, 3H, J = 7.0 Hz, CH3); 1.25-1.31 (m, 18H, CH2); 1.47-1.54 (m, 2H, Alk-CH2-CH2-N); 1.97- 2.05 (m, 2H, CO-CH2-CH2-CH2-N); 2.38 (t, 2H, J = 8.0 Hz, CO-CH2-CH2-CH2-N); 3.26 (t, 2H, J = 7.5 Hz, Alk-CH2-CH2-N); 3.37 (t, 2H, J = 7.0 Hz, CO-CH2-CH2-CH2- N).13C NMR (100 MHz, CDCl3) δ (ppm): 14.3 (CH3); 18.1 (CO-CH2-CH2-CH2-N); 22.9; 27.0 (CH2alk); 27.5 (Alk-CH2-CH2-N); 29.5; 29.7; 29.8; 29.9 (CH2alk); 31.3 (CO-CH2-CH2-CH2-N); 32.1 (CH2alk); 42.7 (Alk-CH2-CH2-N); 47.2 (CO-CH2-CH2-CH2-N); 174.9 (CO).

References

[1] Patent: US2015/133688, 2015, A1. Location in patent: Page/Page column

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