VASICINONE Chemical Properties

Melting point:

200-202℃

Boiling point:

320.7°C (rough estimate)

Density 

1.50

refractive index 

1.5300 (estimate)

solubility 

Soluble in chloroform and ethanol;

form 

powder

pka

12.76±0.20(Predicted)

color 

White

Water Solubility 

1.597g/L(25 ºC)

VASICINONE Usage And Synthesis

Description

A further alkaloid present in Adhatoda vasica and Peganum harmala, this base forms colourless crystals from 95 per cent EtOH. It has [α]²²_D - 100° (c 0.5, CHCL3) and the ultraviolet spectrum has absorption maxima at 227, 272, 302 and 315 mfJ.. The alkaloid yields a series of crystalline salts with mineral acids, e.g. the hydrochloride, m.p. 232-4°C; hydro bromide, m.p. 254-5°C (dec.); hydriodide, m.p. 222-6°C (dec.); nitrate, m.p. 138-9° C (dec.) and the sulphate, m.p. l82-5°C (dec.). The optically inactive form of the base has been prepared synthetically, m.p. 211- 2°C. The alkaloid is an active bronchodilator.

Definition

ChEBI: Vasicinone is a member of quinazolines.

target

P450 (e.g. CYP17)

References

Ghose et al., J. Chem. Soc., 2740 (1932)
Morris, Horford, Adams., J. Amer. Chem. Soc., 57,951 (1935)
Mehta, Naravane, Desai., J. Org. Chem., 28, 445 (1963)

VASICINONE(486-64-6)Related Product Information

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