Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  Biochemical Engineering >  Chinese Herbs >  Vasicine

Vasicine

Basic information Safety Supplier Related

Vasicine Basic information

Product Name:
Vasicine
Synonyms:
  • 1-b)quinazolin-3-ol,1,2,3,9-tetrahydro-pyrrolo(
  • vasicin
  • 1,2,3,9-TETRAHYDROPYRROLO[2,1-B]QUINAZOLIN-3-OL
  • AKOS NCG1-0080
  • VITAS-BB TBB000541
  • VASICINE
  • PEGANINE
  • C10733
CAS:
6159-55-3
MF:
C11H12N2O
MW:
188.23
EINECS:
228-180-8
Product Categories:
  • Miscellaneous Natural Products
  • Alkaloids
Mol File:
6159-55-3.mol
More
Less

Vasicine Chemical Properties

Melting point:
211.5°C
Boiling point:
323.23°C (rough estimate)
Density 
1.1124 (rough estimate)
refractive index 
1.5850 (estimate)
solubility 
DMSO : 83.33 mg/mL (442.70 mM; Need ultrasonic)
form 
Powder
pka
13.08±0.20(Predicted)
More
Less

Safety Information

Hazard Codes 
Xn
Risk Statements 
22
RIDADR 
1544
HazardClass 
6.1(b)
PackingGroup 
III
More
Less

Vasicine Usage And Synthesis

Description

This quinazoline alkaloid was first isolated from the leaves of Adhatoda vasica Nees by Hooper and subsequently discovered in Peganum harmala under the name Peganine. The base is optically inactive although Spath and Kesztler have reported the isolation of the (-)-form from the fresh leaves of A. vasica and Rosenfeld and Kolesnikow have obtained the same form from the flowers and stems of Peganum harmala. The salts are readily obtained crystalline, e.g. the hydrochloride dihydrate, m.p. 208°C (dry); hydriodide dihydrate, m.p. 195°C (dry); picrate, m.p. 199°C (dec.) and the methiodide, m.p. 187°C.
With AcOH, the alkaloid gives an anomalous acetyl derivative, m.p. 165°C, subsequently shown to be N-acetylpedadiene. Oxidation with KMn04 gives 4-quinazolone and 4-keto-3 :4-dihydroxyquinazolyl-3-acetic acid, the latter characterized as the methyl ester, m.p. 152°C.
The crude drug from A. vasica is used in India as a remedy for asthma while the pure alkaloid acts as a bronchodilator.

Chemical Properties

White needle-like crystals, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from camels.

Biological Activity

Vasicine, isolated from A. vasica, is an alkaloid. It is a natural cholinesterase (cholinesterase) inhibitor, has anticholinesterase activity in preclinical models, and can be used for the development of therapeutic drugs for Alzheimer's disease.

target

Antifection | AChR

References

Hooper., Pharm. J., 18,841 (1888)
Sen, Ghose.,J. Ind. Chem. Soc., 1,315 (1924)
Ghose., ibid, 4, 1 (1927)
Spath, Nakawitz., Ber., 67,45 (1934)
Spath, Kuffner., ibid, 67, 1494 (1934)
Narang, Ray., Chem. & Ind., 53,698 (1934)
Hanford, Liang, Adams., J. Amer. Chem. Soc., 56, 2780 (1934)
Ghoseetal., ibid, 57,921,951 (1935)
Rosenfeld, Kolesnikov., Ber., 69, 2022 (1936)
Pharmacology: Chopra., Ind. Med. Gaz., 60, 354 (1925)
Tutaev, Makarova., Trans. Ukraine Inst. Exp. Pharm., 1,32 (1938)

VasicineSupplier

Huzhou ZhanShu Biotechnology Co.,Ltd Gold
Tel
0572-8889530 18167260939
Email
zsubio@163.com
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Email
sales@BioChemBest.com
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Email
sj_scrc@sinopharm.com
BioBioPha Co., Ltd.
Tel
0871-65217109 13211707573;
Email
y.liu@mail.biobiopha.com
Chengdu Biopurify Phytochemicals Ltd.
Tel
+86-028-82633397 18982077548
Email
cwb1@biopurify.cn