1-Boc-5-aminoindole Chemical Properties

Boiling point:

384.2±34.0 °C(Predicted)

Density 

1.16±0.1 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

4.28±0.10(Predicted)

form 

low melting solid

color 

Brown

CAS DataBase Reference

166104-20-7(CAS DataBase Reference)

Safety Information

HS Code 

2933998090

1-Boc-5-aminoindole Usage And Synthesis

Synthesis

General procedure for the synthesis of N-Boc-5-aminoindole from tert-butyl 5-nitro-1H-indole-1-carboxylate: tert-butyl 5-nitro-1H-indole-1-carboxylate (525 mg, 2.0 mmol) was dissolved in ethyl acetate (8 mL), and 10% palladium-carbon-catalyst (50 mg) was added. The reaction mixture was stirred overnight at room temperature in a hydrogen atmosphere. Upon completion of the reaction, the catalyst was removed by suction filtration and the filtrate was concentrated under reduced pressure to afford the white solid product N-Boc-5-aminoindole (469 mg, 100% yield).

References

[1] Patent: CN104311541, 2017, B. Location in patent: Paragraph 0164; 0165
[2] Patent: US2009/247568, 2009, A1. Location in patent: Page/Page column 36
[3] Journal of Medicinal Chemistry, 2013, vol. 56, # 15, p. 6273 - 6277
[4] Synthetic Communications, 2006, vol. 36, # 14, p. 2069 - 2077
[5] Journal of Medicinal Chemistry, 2011, vol. 54, # 4, p. 1106 - 1110

1-Boc-5-aminoindole(166104-20-7)Related Product Information

• BUTYL OLEATE
• Indole-3-butyric acid
• Tris(trimethylsilyl)phosphate
• 5-Amino-2-methylpyridine
• 4-Aminobenzoic acid
• Indole-3-acetic acid
• tert-Butanol
• Indometacin
• POLYURETHANE
• tert-Butyl peroxybenzoate
• Urethane
• tert-Butyl peroxyacetate
• Indole
• 5-Aminoindole
• Cyhalofop-butyl
• Butyl acetate
• Methyl anthranilate
• Buprofezin