(R)-(+)-1-(4-PYRIDYL)ETHANOL CAS#: 27854-88-2

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(R)-(+)-1-(4-PYRIDYL)ETHANOL

Basic information Reaction Safety Supplier Related

(R)-(+)-1-(4-PYRIDYL)ETHANOL Basic information

Product Name:

(R)-(+)-1-(4-PYRIDYL)ETHANOL

Synonyms:

4-[(R)-1-Hydroxyethyl]pyridine
(R)-4-(1-Hydroxyethyl)pyridine,99+%,(99+% ee)
(R)-4-(1-Hydroxyethyl)pyridine(R)-(+)-1-(4-Pyridyl)ethanol
(R)-1-(pyridin-4-yl)ethanol
(1R)-1-(pyridin-4-yl)ethan-1-ol
4-PyridineMethanol, α-Methyl-, (R)-
(aR)-a-Methyl-4-PyridineMethanol
(R)-(+)-alpha-Methyl-4-pyridinemethanol 99%

CAS:

27854-88-2

MF:

C7H9NO

MW:

123.15

Product Categories:

Alcohols, Hydroxy Esters and Derivatives
Chiral Compounds

Mol File:

27854-88-2.mol

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(R)-(+)-1-(4-PYRIDYL)ETHANOL Chemical Properties

Melting point:: 67-69 °C(lit.)
Boiling point:: 239.7±15.0 °C(Predicted)
Density: 1.082±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,2-8°C
solubility: soluble in Methanol
pka: 13.52±0.20(Predicted)
form: Crystalline Powder or Needles
color: White
optical activity: [α]20/D +55°, c = 1 in chloroform
BRN: 4306037
InChIKey: HVOAMIOKNARIMR-ZCFIWIBFSA-N

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Safety Information

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
F: 3-10
HS Code: 29333999

MSDS

Language:English Provider:SigmaAldrich

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(R)-(+)-1-(4-PYRIDYL)ETHANOL Usage And Synthesis

Reaction

Used for the synthesis of chiral 1-(4-pyridinyl)ethylamines
Precursor for intermediates of highly stable chiral (A)6-B Supramolecular Copolymers

Chemical Properties

White needles

Uses

(1R)-1-(4-Pyridyl)ethanol is a building block reagent used in the synthesis of potent GPR119 receptor agonists used in the treatment of diabetes.

Purification Methods

Purify it by recrystallisation from pet ether. The m recorded after sublimation was 59.9-60.2o, and 55o after crystallisation from *C6H6/pet ether or pet ether/*C6H6. The (-)-di-O-benzoyl tartrate salt has m 146-148o (from EtOH). [UV, ORD: Harelli & Samori J Chem Soc Perkin Trans 2 1462 1974.] The racemate recrystallises from Et2O with m 74-76o,b 90-94o/1mm. The picrate has m 125-126o (from *C6H6). [Ferles & Attia Collect Czech Chem Commun 38 611 1973, UV, NMR: Nielson et al. J Org Chem 29 2898 1964, Beilstein 21 III/IV 522, 21/2 V 217.]

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