1-Bromohexane Chemical Properties

Melting point:

−85 °C(lit.)

Boiling point:

154-158 °C(lit.)

Density 

1.176 g/mL at 25 °C(lit.)

vapor density 

5.7 (vs air)

vapor pressure 

<10 mm Hg ( 20 °C)

refractive index 

n20/D 1.448(lit.)

Flash point:

135 °F

storage temp. 

Store below +30°C.

solubility 

<1g/l

form 

Liquid

color 

Clear

Water Solubility 

Immiscible with water.

BRN 

1731290

Dielectric constant

5.8（24℃）

Stability:

Stable. Incompatible with strong oxidizing agents, strong bases. Combustible.

InChIKey

MNDIARAMWBIKFW-UHFFFAOYSA-N

CAS DataBase Reference

111-25-1(CAS DataBase Reference)

NIST Chemistry Reference

Hexane, 1-bromo-(111-25-1)

EPA Substance Registry System

Hexane, 1-bromo- (111-25-1)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38-10

Safety Statements 

26-36-16

RIDADR 

UN 1993 3/PG 3

WGK Germany 

2

RTECS 

MO0925000

TSCA 

Yes

HazardClass 

3

PackingGroup 

III

HS Code 

29033036

Toxicity

LD50 orally in Rabbit: > 2000 mg/kg

MSDS

• Language:English Provider:1-Bromohexane
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

1-Bromohexane Usage And Synthesis

Chemical nature

1-Bromohexane is organobromine compound with formula Br(CH2)5CH3. It is a colorless liquid.

Synthesis and reactions

Most 1-bromoalkanes are prepared by free-radical addition of hydrogen bromide to the 1-alkene. These conditions lead to anti-Markovnikov addition, giving the 1-bromo derivative.
1-Bromohexane undergoes reactions expected of simple alkyl bromides. It can form Grignard reagents. It reacts with potassium fluoride to give the corresponding fluorocarbons.

Chemical Properties

1-Bromohexane is a colourless liquid organohalide. It is a solvent that is frequently used in grignard reactions. It is also used as Intermediate, for introduction of hexyl group.

Uses

1-Bromohexane is utilized in the preparation of pharmaceuticals and organic chemicals. It is involved in Grignard reactions as an alkylating agent and in the synthesis of bromo-cyclic compounds.

Application

1-Bromohexane is a very useful synthetic intermediate，it can be used to react with Mg to prepare Grignard reagents which play an important role in formation of carbon-carbon bond.

Synthesis Reference(s)

Chemistry Letters, 7, p. 833, 1978
Synthetic Communications, 6, p. 21, 1976 DOI: 10.1080/00397917608062128
Tetrahedron, 40, p. 641, 1984 DOI: 10.1016/S0040-4020(01)91092-0

Purification Methods

Shake the bromide with H2SO4, wash with water, dry (K2CO3) and fractionally distil. [Beilstein 1 IV 352.]

1-Bromohexane(111-25-1)Related Product Information

• 1-Bromobutane
• 1-Bromopentane
• Broxuridine
• Cyanogen bromide
• 1-Bromooctane
• 1-Bromohexadecane
• 1-Bromooctadecane
• 1-Bromononane
• 1-Bromoheptane
• Bromopentafluorobenzene
• Cuprous bromide
• Bromoacetic acid
• 4-Bromomethyl-1,2-dihydroquinoline-2-one
• Sodium bromide
• Calcium bromide
• Benzyl bromide
• Bromoacetyl bromide
• Bromoethane