N6-CYCLOHEXYLADENOSINE Chemical Properties

Melting point:

182 - 184°C

Boiling point:

675.2±65.0 °C(Predicted)

Density 

1.71±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)

form 

Solid

pka

13.12±0.70(Predicted)

color 

White to Off-White

Stability:

Hygroscopic

Safety Information

WGK Germany 

3

HS Code 

29349990

MSDS

• Language:English Provider:SigmaAldrich

N6-CYCLOHEXYLADENOSINE Usage And Synthesis

Description

N⁶-Cyclohexyladenosine is an adenosine receptor agonist. It selectively binds to adenosine A₁ receptors in rat cortical membranes (IC₅₀ = 2.3 nM) over A₂ receptors in rat striatal membranes (IC₅₀ = 870 nM). N⁶-Cyclohexyladenosine decreases heart rate and increases coronary flow in a perfused working rat heart model ex vivo (EC₂₅s = 5 and 860 nM, respectively). In vivo, it decreases heart rate and blood pressure in normotensive rats (EC₂₅s = 2.4 and 4.2 μg/kg, respectively). N⁶-Cyclohexyladenosine (100 μM) induces sleep in rats when administered via basal forebrain infusion. N⁶-Cyclohexyladenosine also decreases locomotor activity in mice (ED₅₀ = 60 μg/kg, i.p.).

Uses

N6-Cyclohexyladenosine is a derivative of Adenosine (A280400), and is used testing adenosine A1 and A2A receptor activation for pharmaceuticals such as antidepressants. N6-Cyclohexyladenosine also is used as a JAK2 inhibitor, blocking STAT3 signalling in human cancer cells.

Biochem/physiol Actions

Selective A1 adenosine receptor agonist.

storage

Store at -20°C

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