6-(METHYLAMINO)PURINE Chemical Properties

Melting point:

≥300 °C

Boiling point:

256.3±50.0 °C(Predicted)

Density 

1.57±0.1 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

DMSO (Slightly, Heated), Methanol (Slightly, Heated)

form 

Solid

pka

9.61±0.20(Predicted)

color 

White to Light Grey

CAS DataBase Reference

443-72-1

Safety Information

WGK Germany 

3

F 

10-23

HS Code 

2933998090

MSDS

• Language:English Provider:SigmaAldrich

6-(METHYLAMINO)PURINE Usage And Synthesis

Uses

N6-Methyladenine is a modified purine that is commonly found in genomes of prokaryotes, protists, and plants. It is less common in higher eukaryotes and extremely rare in mammals. Like methylation of other DNA residues, N6-methyladenine represents an epigenetic modification that can affect diverse DNA functions, including replication, repair, and expression.

Uses

6-(Methylamino)purine, 6-methylade is a reagent for substitution of adenine nucleotide analogs containing bicyclohexane ring system locked in northern conformation enhanced potency as py receptor antagonists. Adenine methylation as an epigenic mark has been observed in single-celled organisms and also rarely in mamalian cells.

Definition

ChEBI: A 6-alkylaminopurine that is 9H-purin-6-amine substituted by a methyl group at the amino nitrogen.

Purification Methods

The purine is best purified by recrystallising 2g from 50mL of H2O and 1.2g of charcoal. [UV: Albert & Brown J Chem Soc 2060 1954; UV: Mason J Chem Soc 2071 1954; see also Elion et al. J Am Chem Soc 74 411 1952.] The picrate has m 265o(257o) [Bredereck et al. Chem Ber 81 307 1948]. [Beilstein 26 III/IV 3565.]

6-(METHYLAMINO)PURINE(443-72-1)Related Product Information

• DMT-dA(bz) Phosphoramidite
• 6-Benzylaminopurine
• N6-ISOPENTENYLADENOSINE-D6
• Bucladesine sodium
• TRANS-ZEATIN RIBOSIDE
• N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine
• PUROMYCIN DIHYDROCHLORIDE
• 6-Dimethylaminopurine
• N6-Benzoyl-2'-deoxyadenosine
• N6-CYCLOHEXYLADENOSINE
• N6-BENZYLADENOSINE
• N6,N6-DIMETHYLADENOSINE
• 6-(METHYLAMINO)PURINE RIBOSIDE
• N6-CYCLOPENTYLADENOSINE
• 6-DODECYLADENINE
• 6-METHYLAMINOPURINE 9-RIBOFURANOSIDE
• 6-PIPERIDINOPURINE
• 2-CHLORO-6(METHYLAMINO)PURINE