Bucladesine sodium
Bucladesine sodium Basic information
- Product Name:
- Bucladesine sodium
- Synonyms:
-
- dibutylcyclicampsodium
- dibutylcyclicampsodiumsalt
- dt5621sodiumsalt
- e,butyrate(ester),monosodiumsalt
- monosodiumdibutyrylcyclicamp
- n-(9-beta-d-ribofuranosyl-9h-purin-6-yl)-butyramidcyclichydrogenphosphat
- n6,02’-dibutyryladenosine3’,5’-cyclicmonophosphatesodiumsalt
- n6,2’-o-dibutyryladenosine-3’,5’-cyclicmonophosphate(dbcamp),sodiumsalt
- CAS:
- 16980-89-5
- MF:
- C18H25N5NaO8P
- MW:
- 493.39
- EINECS:
- 241-059-4
- Product Categories:
-
- Cyclic Nucleotide related
- API
- 16980-89-5
- Mol File:
- 16980-89-5.mol
Bucladesine sodium Chemical Properties
- Melting point:
- >173°C (dec.)
- storage temp.
- -20°C
- solubility
- H2O: 50 mg/mL
- form
- powder
- color
- white
- Merck
- 14,1463
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
- InChIKey
- DBXVIQJWMFGXGO-AOTDUVMNNA-N
- SMILES
- O([C@@H]1[C@]2([H])OP(O)(=O)OC[C@@]2([H])O[C@H]1N1C=NC2C(=NC=NC1=2)NC(=O)CCC)C(=O)CCC.[NaH] |&1:1,2,10,13,r|
MSDS
- Language:English Provider:SigmaAldrich
Bucladesine sodium Usage And Synthesis
Description
Bucladesine sodium is a derivative of cyclic-AMP with cardiac stimulant and peripheral vasodilatory properties. It is reported to be useful in cardiac insufficiency, especially after heart surgery.
Originator
Daiichi Seiyaku; Seishin Seiyaku (Japan)
Uses
Bucladesine sodium is an analog of cyclic AMP that stimulates cAMP-dependent protein kinase. It has vasodilator properties and is used as a cardiac stimulant.
Definition
ChEBI: Bucladesine sodium is a 3',5'-cyclic purine nucleotide.
Application
N6,2′-O-Dibutyryladenosine 3′,5′-cyclic monophosphate sodium salt has been used:
as a medium supplement for neural crest stem cells (NCSCs) differentiation
as a component of thawing medium for cryopreserved human iPSC (induced pluripotent stem cell)-derived neurons
in serum-free Dulbecco′s modified eagle′s medium (DMEM) to induce astrocyte differentiation
brand name
ACTOCIN
General Description
A cell-permeable cAMP analog that preferentially activates cAMP-dependent protein kinase (PKA). Causes an increase in the steady state level of parathyroid hormone-related peptide mRNA. Also acts as a Hh pathway antagonist. Shown to induce apoptosis in vascular smooth muscle cells.
Biochem/physiol Actions
Cell-permeable cAMP analog that activates cAMP dependent protein kinase (PKA).
storage
Store at -20°C
References
1) Bartsch?et al.?(2003),?Bioactivatable, membrane-permeant analogs of cyclic nucleotides as biological tools for growth control of C6 glioma cells; Biol. Chem.,?384?1321
2) Carranza?et al.?(1998),?Protein kinase A induces recruitment of active Na+,K+-ATPase units to the plasma membrane of rat proximal convoluted tubule cells; J. Physiol.,?15?511
3) Hei?et al.?(1991),?Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs; Mol. Pharmacol.,?39?233
4) Imamura?et al.?(1998),?Differential expression of dystrophin isoforms and utrophin during dibutyryl-cAMP-induced morphological differentiation of rat brain astrocytes; Proc. Natl. Acad. Sci. USA,?95?6139
5) Xia?et al.?(2016),?Transcriptional comparison of human induced and primary midbrain dopaminergic neurons; Sci. Rep.,?6?20270
Bucladesine sodiumSupplier
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Bucladesine sodium(16980-89-5)Related Product Information
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- NAD+
- 8-CHLORO-CAMP
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- MALANTIDE
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- HA-1004 DIHYDROCHLORIDE
- ARG-ARG-LYS-ALA-SER-GLY-PRO
- 8-(4-CHLOROPHENYLTHIO)-ADENOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT
- Bucladesine (calciuM salt)
- 6-MB-CAMP SODIUM SALT
- 2'-O-MB-CAMP SODIUM SALT
- SP-ADENOSINE 3',5'-CYCLIC MONOPHOSPHOTHIOATE TRIETHYLAMINE
- 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT
- PROTEIN KINASE A INHIBITOR 14-22 AMIDE, CELL-PERMEABLE, MYRISTOYLATED
- Butyramide
- Cyclic AMP
- Bucladesine