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LUPEOL ACETATE

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LUPEOL ACETATE Basic information

Product Name:
LUPEOL ACETATE
Synonyms:
  • LUPEOL ACETATE
  • 3-Acetyllupeol
  • LUPEOL ACETATE(RG)
  • 3-O-Acetyllupeol
  • Lup-20(29)-en-3beta-ol, acetate
  • Lup-20(29)-en-3-ol, acetate, (3beta)-
  • Lup-20(29)-en-3-yl acetate
  • Lupenyl acetate
CAS:
1617-68-1
MF:
C32H52O2
MW:
468.75
EINECS:
216-575-8
Product Categories:
  • Tri-Terpenoids
Mol File:
1617-68-1.mol
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LUPEOL ACETATE Chemical Properties

Melting point:
218°C
Boiling point:
502.7±19.0 °C(Predicted)
Density 
1.01±0.1 g/cm3(Predicted)
form 
Solid
color 
White to off-white
InChIKey
ODSSDTBFHAYYMD-NVDDSYLUNA-N
SMILES
[C@@]12(C)CC[C@@]3(C)CC[C@@H](C(=C)C)[C@]3([H])[C@@]1([H])CC[C@]1([H])[C@@]3(C)CC[C@H](OC(=O)C)C(C)(C)[C@]3([H])CC[C@@]21C |&1:0,4,8,12,14,18,20,24,32,36,r|
LogP
11.870 (est)
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LUPEOL ACETATE Usage And Synthesis

Uses

antiulcer

Definition

ChEBI: Lupeol acetate is an organic molecular entity. It has a role as a metabolite.

in vivo

Lupeol acetate (50 mg/kg; Intraperitoneal injection; 21 days) shows improvement in the mouse model of rheumatoid arthritis[3].
Lupeol acetate (10 mg/day; Oral administration; 60 days) plays an anti-fertility role in male rats[4].

Animal Model:DBA/1J mouse aged 8 weeks old with collagen-induced arthritis[3]
Dosage:50 mg/kg
Administration:Intraperitoneal injection (i.p.); 21 days
Result:Reduced the incidence of arthritis and relieved symptoms of rheumatoid arthritis.
Significantly decreased clinical score and paw thickness.
Significantly lowered TNF-α and IL-1β levels in serum.
Inhibited inflammatory activity, significantly decreased the accumulation of 18F-FDG in the joints.
Reduced the infiltration of macrophages and bone erosion.
Animal Model:Male albino rats of the Wistar strain aged 3.5-4 months old (170 and 200 g)[4]
Dosage:10 mg/day
Administration:Oral administration (p.o.); 60 days
Result:Did not cause any significant change in the body weights, but significantly reduced in the weight of reproductive organs, i.e. testes, epididymides, seminal vesicle and ventral prostate.
Significantly declined testicular sperm count, epididymal sperm count and motility, which resulted in reduction of male fertility by 100%.
Interfered with spermatogenesis and significantly reduced most tubule cell types.
Significantly reduced biochemical parameters of tissues i.e. protein, sialic acid, glycogen and cholesterol content of testes and seminal vesicular fructose.

IC 50

COX-2

LUPEOL ACETATESupplier

Shanghai Taopu Industrial Co., LTD Gold
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159-00573766 18018507602
Email
394643792@qq.com
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Email
market03@meryer.com
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
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3007715519@qq.com
BioBioPha Co., Ltd.
Tel
0871-65217109 13211707573;
Email
y.liu@mail.biobiopha.com
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Email
tauto@tautobiotech.com
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