Chloromethanesulfonyl chloride Chemical Properties

Boiling point:

80-81°C

Density 

1.64 g/mL at 20 °C(lit.)

refractive index 

1.488

Flash point:

110.00°C

storage temp. 

-20°C

solubility 

Chloroform, Methanol

form 

Liquid

Specific Gravity

1.67

color 

White

Water Solubility 

It is soluble in dichloromethane, pyridine, and most organic solvents. It is insoluble in water.

Sensitive 

Moisture Sensitive

BRN 

1811761

InChI

1S/CH2Cl2O2S/c2-1-6(3,4)5/h1H2

InChIKey

KQDDQXNVESLJNO-UHFFFAOYSA-N

SMILES

ClCS(Cl)(=O)=O

CAS DataBase Reference

3518-65-8(CAS DataBase Reference)

NIST Chemistry Reference

Chloromethanesulfonyl chloride(3518-65-8)

Safety Information

Hazard Codes 

C,Xi

Risk Statements 

22-34

Safety Statements 

26-36/37/39-45

RIDADR 

UN 3265 8/PG 2

WGK Germany 

3

RTECS 

PB2800000

F 

10-21

Hazard Note 

Corrosive

HazardClass 

8

PackingGroup 

I

HS Code 

2904990090

Storage Class

8A - Combustible corrosive hazardous materials

Hazard Classifications

Acute Tox. 4 Oral
Skin Corr. 1B

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Chloromethanesulfonyl chloride Usage And Synthesis

Uses

Chloromethanesulfonyl Chloride is a very useful intermediate for organic synthesis. It enhances citric acid production by Aspergillus niger NCIM-1696 and increases the yield of citric acid. It also functions as a useful intermediate for pharmaceutical synthesis.

Synthesis

Chloromethylsulfonyl chloride is synthesized as follows: add Na2SO3252g, 500g of water, 504g of methylene chloride, I1.25g of cetyltrimethylammonium chloride to 2000ml of the reactor with a pressure and temperature detecting device, warm up to 0.2MPa pressure in the reactor and keep pressure to react for 3hr, stop the reaction, cool down, unload the reactor and remove the water and unreacted solvent by distillation. Unreacted solvent was removed by distillation and dried to obtain the product I260 g. Yield: 95%.

The above synthesized product I was added to 2000 ml reaction bottle with thermometer, drying and distillation device, add methanol 260g, triethylamine 1.04g, slowly raise the temperature to T = 40 ??, maintain the temperature, in 30min, through the chlorine gas 13g, keep warm to react 3.5hr, the end of the reaction. The solvent was removed by distillation. Obtained crude product, at a temperature of T = 70-80 ??, vacuum degree of 0.08-0.1MPa conditions, distillation, the product 240g. 85% yield.

Chloromethanesulfonyl chloride(3518-65-8)Related Product Information

• Mepiquat chloride
• Sodium chloride
• Benzyl chloride
• alpha-Toluenesulfonyl chloride
• Benzenesulfonyl chloride
• 4-Nitrobenzenesulfonyl chloride
• Choline chloride
• Tosyl chloride
• Ammonium chloride
• Polyvinyl chloride
• Ethanesulfonyl chloride
• Calcium chloride
• Sulfuryl chloride
• Methanesulfonyl chloride
• Methylene Chloride
• Trichloromethanesulfonyl chloride
• DICHLOROMETHANESULFONYL CHLORIDE
• Methanesulfonic acid