ZEBULARINE
ZEBULARINE Basic information
- Product Name:
- ZEBULARINE
- Synonyms:
-
- Zebularine - CAS 3690-10-6 - Calbiochem
- NSC309132;4-DEOXYURIDINE
- 1-(β-d-ribofuranosyl)-1,2-dihydropyrimidin-2-one
- pyrimidin-2-one beta-ribofuranoside
- 1--D-Ribofuranosyl-2(1H)-pyrimidinone
- 4-Deoxyuridine
- NSC 309132
- Pyrimidin-2-one -D-Ribofuranoside
- CAS:
- 3690-10-6
- MF:
- C9H12N2O5
- MW:
- 228.2
- EINECS:
- 2017-001-1
- Product Categories:
-
- Carbohydrates & Derivatives
- Inhibitors
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 3690-10-6.mol
ZEBULARINE Chemical Properties
- Melting point:
- 160-162?C
- Boiling point:
- 499.0±55.0 °C(Predicted)
- Density
- 1.73±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: 16 mg/mL, soluble
- form
- solid
- pka
- 13.48±0.70(Predicted)
- color
- White
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
- InChIKey
- RPQZTTQVRYEKCR-WCTZXXKLSA-N
ZEBULARINE Usage And Synthesis
Description
Zebularine (3690-10-6) is an orally active DNA methyltransferase inhibitor. Inhibits tumor cell proliferation (IC50 = 120 μM) and re-activates silenced genes in T24 bladder carcinoma cells. Zebularine inhibits cytidine deaminase (Ki ~ 2 μM and; induces differentiation of mesenchymal stem cells into cardiomyocytes.
Chemical Properties
White Solid
Uses
It is a cytidine analogue, cytidine deaminase inhibitor, and DNA demethylating agent.
Definition
ChEBI: Zebularine is a member of pyrimidine ribonucleosides.
Biological Activity
Orally active DNA methyltransferase inhibitor. Inhibits tumor cell proliferation (IC 50 = 120 μ M) and re-activates silenced genes in T24 bladder carcinoma cells. Also inhibits cytidine deaminase (K i ~ 2 μ M).
Biochem/physiol Actions
Zebularine is a cytidine analogue, cytidine deaminase inhibitor, and DNA demethylating agent.
storage
Desiccate at RT
ZEBULARINESupplier
- Tel
- 0371-65325800 13700860222
- haifeng.zhang@pannacean.com
- Tel
- 0371-85513397 +86-18610099868;
- info@granlen.com
- Tel
- 19308655899
- 2677609105@qq.com
- Tel
- 010-82848833 400-666-7788
- jkinfo@jkchemical.com
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
ZEBULARINE(3690-10-6)Related Product Information
- 5-METHYLCYTIDINE
- 6-[(3-chloropropyl)amino]-1,3-dimethyluracil
- URAPIDIL 5-METHYL-
- Uridine 5''-Monophosphate N,N-Dibutyl-1-butanamine
- Pseudouridine
- 6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione
- 2-Demethoxy-4-methoxy urapidil
- Quillaic acid
- (8α,9β,14β,23S,24R)-11β,23-Dihydroxy-24,25-epoxy-5α-dammar-13(17)-ene-3,16-dione
- Alisol B acetate
- SAPONIN, PRACT. FROM QUILLAJA SAPONARIA MOLINA
- Anisodine hydrobromide
- velutin
- Zearalenone
- Urapidil Impurity 20
- 2,4(1H,3H)-Pyrimidinedione, 5-[5-O-[(1,1-dimethylethyl)diphenylsilyl]-β-D-ribofuranosyl]-
- 2,4(1H,3H)-Pyrimidinedione, 1-α-L-arabinofuranosyl-
- 2,4(1H,3H)-Pyrimidinedione, 1-β-L-arabinofuranosyl-