3 Hydroxy Midostaurin Epimer 1 (CGP52421 Epimer 1)
3 Hydroxy Midostaurin Epimer 1 (CGP52421 Epimer 1) Basic information
- Product Name:
- 3 Hydroxy Midostaurin Epimer 1 (CGP52421 Epimer 1)
- Synonyms:
-
- 3 Hydroxy Midostaurin Epimer 1 (CGP52421 Epimer 1)
- (S)-3-Hydroxy Midostaurin
- (S)-CGP52421
- Midostaurin Impurity 1
- Midostaurin Impurity 3
- Benzamide, N-[(3S,9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl-
- P37.7 (CGP52421 Epimer 1)
- (S) 3 Hydroxy Midostaurin,(S)3Hydroxy Midostaurin
- CAS:
- 945260-14-0
- MF:
- C35H30N4O5
- MW:
- 586.64
- Mol File:
- 945260-14-0.mol
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3 Hydroxy Midostaurin Epimer 1 (CGP52421 Epimer 1) Chemical Properties
- Melting point:
- 298-301 °C
- Density
- 1.53±0.1 g/cm3(Predicted)
- pka
- 12.23±0.70(Predicted)
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3 Hydroxy Midostaurin Epimer 1 (CGP52421 Epimer 1) Usage And Synthesis
Uses
(S)-3-Hydroxy Midostaurin ((S)-CGP52421) is a potent kinases inhibitor with IC50 values of <400 nM for 13 kinases (VEGFR-2, TRK-A, FLT3, et). (S)-3-Hydroxy Midostaurin is a minor metabolite of midostaurin (PKC412; HY-10230) undergoing by the hepatic CYP3A4 enzyme. (S)-3-Hydroxy Midostaurin has the potential for acute myeloid leukemia (AML)[1].
References
[1] Manley PW, et al. Comparison of the Kinase Profile of Midostaurin (Rydapt) with That of Its PredominantMetabolites and the Potential Relevance of Some Newly Identified Targets to Leukemia Therapy. Biochemistry. 2018 Sep 25;57(38):5576-5590. DOI:10.1021/acs.biochem.8b00727
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