Basic information Safety Supplier Related

CGP52421

Basic information Safety Supplier Related

CGP52421 Basic information

Product Name:
CGP52421
Synonyms:
  • CGP52421
  • 3-Hydroxy Midostaurin (CGP 52421)
  • 3-Hydroxy Midostaurin
  • Benzamide, N-(2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl)-N-methyl-
  • Midostaurin Impurity 1 (3-Hydroxy Midostaurin)
  • 3-Hydroxy Midostaurin D5Q: What is 3-Hydroxy Midostaurin D5 Q: What is the CAS Number of 3-Hydroxy Midostaurin D5
  • Midostaurin metabolite - CGP52421
  • N-[(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl benzamide
CAS:
179237-49-1
MF:
C35H30N4O5
MW:
586.65
Mol File:
179237-49-1.mol
More
Less

CGP52421 Chemical Properties

Density 
1.53±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Solid
pka
12.23±0.70(Predicted)
color 
Light yellow to yellow
More
Less

CGP52421 Usage And Synthesis

Uses

3-Hydroxy Midostaurin-d5 is the deuterium labelled 3-Hydroxy Midostaurin (H939985(M)). 3-Hydroxy Midostaurin is a metabolite of Midostaurin (M343760), a compound shown to possess antiproliferative characteristics via inhibition of protein kinase C, kinase insert domain receptor, and c-kit.

Biological Activity

3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, potently inhibits FMS-like tyrosine kinase 3 (FLT3) autophosphorylation with IC50s of 132 nM and 9.8 μM in culture medium and plasma, respectively. Compared to PKC412, 3-Hydroxy Midostaurin is less selective but more cytotoxic.

in vitro

CGP52421 (200, 400, 600, 800, 1000 nM) is more cytotoxic than PKC412 over the dose range 100 to 500 nM.

target

IC50: 132 nM (FLT3 in culture medium) and 9.8 μM (FLT3 in plasma)

CGP52421Supplier

Artis Biotech Co. Ltd.
Tel
0575-18780151478 18582380095
Email
sales@artisbio.com
Chengdu Novel Biomedical Co., Ltd.
Tel
028-85255396 18302801538
Email
cdnovell@163.com
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Chengdu Peter-like Biotechnology Co., Ltd.
Tel
028-81700200 18108052721
Email
2850505130@qq.com
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com