3 Hydroxy Midostaurin Epimer 2 (CGP52421 Epimer 2)
3 Hydroxy Midostaurin Epimer 2 (CGP52421 Epimer 2) Basic information
- Product Name:
- 3 Hydroxy Midostaurin Epimer 2 (CGP52421 Epimer 2)
- Synonyms:
-
- 3 Hydroxy Midostaurin Epimer 2 (CGP52421 Epimer 2)
- (R)-3-Hydroxy Midostaurin
- (R)-CGP52421
- Midostaurin Impurity 2
- Benzamide, N-[(3R,9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl-
- Midostaurin Impurity 4
- P39.8 (CGP52421 Epimer 2)
- CAS:
- 155848-20-7
- MF:
- C35H30N4O5
- MW:
- 586.65
- Mol File:
- 155848-20-7.mol
More
Less
3 Hydroxy Midostaurin Epimer 2 (CGP52421 Epimer 2) Chemical Properties
- Density
- 1.53±0.1 g/cm3(Predicted)
- pka
- 12.23±0.70(Predicted)
More
Less
3 Hydroxy Midostaurin Epimer 2 (CGP52421 Epimer 2) Usage And Synthesis
Uses
(R)-3-Hydroxy Midostaurin ((R)-CGP52421) is a potent kinases inhibitor. (R)-3-Hydroxy Midostaurin is a major metabolite of midostaurin (PKC412; HY-10230) undergoing by the hepatic CYP3A4 enzyme. (R)-3-Hydroxy Midostaurin has the potential for acute myeloid leukemia (AML)[1].
References
[1] Manley PW, et al. Comparison of the Kinase Profile of Midostaurin (Rydapt) with That of Its PredominantMetabolites and the Potential Relevance of Some Newly Identified Targets to Leukemia Therapy. Biochemistry. 2018 Sep 25;57(38):5576-5590. DOI:10.1021/acs.biochem.8b00727
3 Hydroxy Midostaurin Epimer 2 (CGP52421 Epimer 2)Supplier
BOC Sciences
- Tel
- 1-631-485-4226; 16314854226
- info@bocsci.com
Artis Biotech Co. Ltd.
- Tel
- 028-67271278 18628360895
- sales@artisbio.com
Chengdu Novel Biomedical Co., Ltd.
- Tel
- 028-85255396 18302801538
- cdnovell@163.com
TargetMol Chemicals Inc.
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
Guangzhou Dreampharm Biotechnology Co., Ltd.
- Tel
- 020-36607679 19925672674
- 3008233746@qq.com