3,5-DIHYDROXYANISOLE HYDRATE Chemical Properties

Melting point:

78-80 °C(lit.)

Boiling point:

188-189 °C12 mm Hg(lit.)

Density 

1.270

refractive index 

1.4638 (estimate)

Flash point:

123℃

storage temp. 

Refrigerator

solubility 

Chloroform (Slightly), Methanol (Slightly)

pka

9.07±0.10(Predicted)

form 

Solid

color 

Yellow

Water Solubility 

Soluble in water.

BRN 

1423578

LogP

0.910 (est)

CAS DataBase Reference

2174-64-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36/37/38

Safety Statements 

26

WGK Germany 

3

HS Code 

2909500090

MSDS

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3,5-DIHYDROXYANISOLE HYDRATE Usage And Synthesis

Uses

5-Methoxyresorcinol was used in synthesis of isorobustin, substituted linear and angular benzofurocoumarins.

Definition

ChEBI: Flamenol is a member of the class of resorcinols that is phloroglucinol in which one of the phenolic hydrogens has been replaced by a methyl group. It has a role as a Brassica napus metabolite. It is a member of resorcinols and a monomethoxybenzene. It is functionally related to a phloroglucinol.

General Description

Kinetics of the aroxyl radical-scavenging action of 5-methoxyresorcinol has been investigated. The kinetics of reaction of 5,7-diisopropyl-tocopheroxyl radical (Toc) with 5-methoxyresorcinol has been measured by stopped-flow spectrophotometer.

Synthesis

Anhydrous phloroglucinol (25g,0.198 mole) is dissolved in absolutemethyl alcohol (100 ml) and the solution cooled to 18°.Dry hydrogenchloride gas is passed through the solution for 25 min at such a rate thatthe solution does not get saturated (approx. 200 bubbles/min).Themixture is then refluxed for 15 min，cooled immediately to 18° and dryhydrogen chloride gas passed again for25 min. The reaction mixture isallowed to stand for 12 hr and the solvent is removed by distillation invacuo.Great care is taken to remove as much of the solvent as possiblewithout applying any heat (preferably in rotatory evaporator).The residueis poured into water (500 ml) and extracted with ether (4 × 75 ml). The ether solution is dried (anhydrous sodium sulphate) and then distilled.The residual oily product is distilled in vacuo. A small quantity ofo-dimethyl phloroglucinol (5g,16.4 %) distils over first at 185-190°/25 mm and then o-monomethyl phloroglucinol (15g,54.2%) distils over at210° as a viscous oil. The viscous oil solidifies on standing for 2-3 days.M.p.78°.The yields are not consistent and vary according to the extent ofsaturation.

3,5-DIHYDROXYANISOLE HYDRATE(2174-64-3)Related Product Information

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